The Physicochemical Properties and Composition of Liposome Lipids from Lecithin Depending on the Conditions of Their Formation

IF 4.033 Q4 Biochemistry, Genetics and Molecular Biology Biophysics Pub Date : 2024-03-18 DOI:10.1134/S0006350923060179

L. N. Shishkina, D. V. Paramonov, M. A. Klimovich, M. V. Kozlov

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Abstract

The influence of the composition and physicochemical properties of lecithin lipids, the duration of exposure to ultrasound, and centrifugation on the composition and physicochemical properties of liposomes formed from lecithin has been studied. It has been revealed that the intensity of lipid peroxidation has an inverse correlation with the phospholipid level in the total lipid composition of lecithin and a direct correlation with the relative content of cardiolipin in the composition of lecithin phospholipids. It has been shown that the duration of ultrasound exposure and centrifugation causes changes in the composition and properties of the liposome lipids. Decreases in the pH of the medium and the intensity of lipid peroxidation of liposomes were observed under centrifugation. It was revealed that the changes in the ability of the liposome lipids to oxidation depending on the duration of ultrasound exposure and centrifugation are due to the relative changes in the sum percentage of the acidic minor fractions in the composition of their phospholipids.

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卵磷脂脂质体的理化性质和组成取决于其形成条件

摘要研究了卵磷脂脂质的组成和理化性质、暴露于超声波的时间以及离心对卵磷脂形成的脂质体的组成和理化性质的影响。研究发现，脂质过氧化的强度与卵磷脂总脂质成分中磷脂的含量成反比，与卵磷脂磷脂成分中心磷脂的相对含量成正比。研究表明，超声暴露和离心的持续时间会导致脂质体脂质的组成和性质发生变化。在离心过程中，观察到培养基的 pH 值下降，脂质体的脂质过氧化强度降低。研究表明，脂质体脂质氧化能力的变化取决于超声暴露和离心的持续时间，这是由于其磷脂组成中酸性次要组分的总百分比发生了相对变化。

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来源期刊

Biophysics Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

1.20

自引率

0.00%

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期刊介绍： Biophysics is a multidisciplinary international peer reviewed journal that covers a wide scope of problems related to the main physical mechanisms of processes taking place at different organization levels in biosystems. It includes structure and dynamics of macromolecules, cells and tissues; the influence of environment; energy transformation and transfer; thermodynamics; biological motility; population dynamics and cell differentiation modeling; biomechanics and tissue rheology; nonlinear phenomena, mathematical and cybernetics modeling of complex systems; and computational biology. The journal publishes short communications devoted and review articles.