Epidemiological Survey of Congenital Heart Disease Among Children Aged from 2 to 18 in Suo County, Nagqu, Tibet.

IF 1.6 4区 医学 Q4 BIOPHYSICS High altitude medicine & biology Pub Date : 2024-06-01 Epub Date: 2024-03-21 DOI:10.1089/ham.2023.0025
Tian Lin, Huaping Jia, Yunming Li, Yongxing Xu, Bei Zhao, Dong Zheng, Hongfeng Yan, Meihui Zhao, Yanlei Li, Liping Xia, Fengxia Zhou, Cuiping Liu, Ke Ma, Ma Mi, Jianwen Gu
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Abstract

Lin, Tian, Huaping Jia, Yunming Li, Yongxing Xu, Bei Zhao, Dong Zheng, Hongfeng Yan, Meihui Zhao, Yanlei Li, Liping Xia, Fengxia Zhou, Cuiping Liu, Ke Ma, Ma Mi, and Jianwen Gu. Epidemiological survey of congenital heart disease among children aged from 2 to 18 in Suo County, Nagqu, Tibet. High Alt Med Biol. 00:000-000, 2024. Background: Studies have reported the prevalence of congenital heart disease (CHD) in parts of Tibet, but relative epidemiological surveys are rare. We aimed to explore the prevalence of CHD in children and its relationship with family history in Suo County, Nagqu, Tibet, an altitude of 3,980 meters. Methods: We recruited 4,002 children aged 2-18 years. Subjects underwent a family history investigation, cardiac auscultation, and clinical manifestation examination and then received echocardiographic screening. Results: The prevalence of CHD among children in Suo County was 0.97% (39 cases), much higher than the prevalence at sea level. The most common subtype was atrial septal defect, accounting for 53.9% of CHD, followed by patent ductus arteriosus (33.3%) and ventricular septal defect (12.8%). We also found that children whose mothers had previously borne children with CHD had a higher risk of CHD than those without (p = 0.002); other factors related to CHD during pregnancy, such as smoking, drinking, drug use, and viral infection, showed no statistical differences between children with and without CHD. Conclusions: The prevalence of CHD in children in Suo County is much higher than at low altitude, consisting mostly of simple forms with left-to-right shunt, with rare complex CHD. These results support implementing diagnostic and treatment plans to prevent CHD in Suo County.

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西藏那曲地区索县2至18岁儿童先天性心脏病流行病学调查。
林天、贾华平、李云明、徐永兴、赵蓓、郑东、闫红峰、赵美惠、李艳蕾、夏丽萍、周凤霞、刘翠萍、马珂、米嬷嬷、顾建文。西藏那曲地区索县2-18岁儿童先天性心脏病流行病学调查。00:000-000, 2024.背景:有研究报道了西藏部分地区先天性心脏病(CHD)的患病率,但相对流行病学调查却很少见。我们的目的是在海拔 3980 米的西藏那曲地区索县调查儿童先天性心脏病的患病率及其与家族史的关系。研究方法我们招募了 4,002 名 2-18 岁的儿童。受试者接受家族史调查、心脏听诊和临床表现检查,然后接受超声心动图筛查。结果显示索县儿童的先天性心脏病患病率为 0.97%(39 例),远高于海平面地区的患病率。最常见的亚型是房间隔缺损,占 53.9%,其次是动脉导管未闭(33.3%)和室间隔缺损(12.8%)。我们还发现,母亲曾生育过患有先天性心脏病的儿童患先天性心脏病的风险高于未生育过先天性心脏病的儿童(P = 0.002);与孕期先天性心脏病有关的其他因素,如吸烟、饮酒、吸毒和病毒感染,在患有和未患有先天性心脏病的儿童之间没有统计学差异。结论索县儿童的先天性心脏病发病率远高于低海拔地区,主要是左向右分流的单纯型先天性心脏病,复杂型先天性心脏病很少见。这些结果支持在索县实施预防先天性心脏病的诊断和治疗计划。
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来源期刊
High altitude medicine & biology
High altitude medicine & biology 医学-公共卫生、环境卫生与职业卫生
CiteScore
3.80
自引率
9.50%
发文量
44
审稿时长
>12 weeks
期刊介绍: High Altitude Medicine & Biology is the only peer-reviewed journal covering the medical and biological issues that impact human life at high altitudes. The Journal delivers critical findings on the impact of high altitude on lung and heart disease, appetite and weight loss, pulmonary and cerebral edema, hypertension, dehydration, infertility, and other diseases. It covers the full spectrum of high altitude life sciences from pathology to human and animal ecology.
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