Hemorrhoidal disease and its genetic association with depression, bipolar disorder, anxiety disorders, and schizophrenia: a bidirectional mendelian randomization study.

IF 3.8 3区医学 Q2 GENETICS & HEREDITY Human Genomics Pub Date : 2024-03-21 DOI:10.1186/s40246-024-00588-7

Zhiguang Huang, Jian Huang, Chun Kai Leung, Casper Jp Zhang, Babatunde Akinwunmi, Wai-Kit Ming

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Abstract

Background: Hemorrhoids and psychiatric disorders exhibit high prevalence rates and a tendency for relapse in epidemiological studies. Despite this, limited research has explored their correlation, and these studies are often subject to reverse causality and residual confounding. We conducted a Mendelian randomization (MR) analysis to comprehensively investigate the association between several mental illnesses and hemorrhoidal disease.

Methods: Genetic associations for four psychiatric disorders and hemorrhoidal disease were obtained from large consortia, the FinnGen study, and the UK Biobank. Genetic variants associated with depression, bipolar disorder, anxiety disorders, schizophrenia, and hemorrhoidal disease at the genome-wide significance level were selected as instrumental variables. Screening for potential confounders in genetic instrumental variables using PhenoScanner V2. Bidirectional MR estimates were employed to assess the effects of four psychiatric disorders on hemorrhoidal disease.

Results: Our analysis revealed a significant association between genetically predicted depression and the risk of hemorrhoidal disease (IVW, OR=1.20,95% CI=1.09 to 1.33, P <0.001). We found no evidence of associations between bipolar disorder, anxiety disorders, schizophrenia, and hemorrhoidal disease. Inverse MR analysis provided evidence for a significant association between genetically predicted hemorrhoidal disease and depression (IVW, OR=1.07,95% CI=1.04 to 1.11, P <0.001).

Conclusions: This study offers MR evidence supporting a bidirectional causal relationship between depression and hemorrhoidal disease.

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痔疮及其与抑郁症、双相情感障碍、焦虑症和精神分裂症的遗传关联：一项双向泯灭随机研究。

背景：在流行病学研究中，痔疮和精神疾病的发病率很高，而且有复发的趋势。尽管如此，对二者相关性的研究却十分有限，而且这些研究往往受到反向因果关系和残余混杂因素的影响。我们进行了孟德尔随机化（MR）分析，以全面研究几种精神疾病与痔疮疾病之间的关联：方法：我们从大型联盟、芬兰基因研究和英国生物库中获得了四种精神疾病与痔疮的遗传关联。选择与抑郁症、双相情感障碍、焦虑症、精神分裂症和痔疮疾病相关的全基因组显著性水平的遗传变异作为工具变量。使用 PhenoScanner V2 筛选遗传工具变量中的潜在混杂因素。采用双向 MR 估计来评估四种精神疾病对痔疮疾病的影响：我们的分析表明，遗传预测的抑郁症与痔疮疾病风险之间存在明显关联（IVW，OR=1.20,95% CI=1.09~1.33，P 结论：该研究提供了支持双向MR估计的证据：本研究提供了 MR 证据，支持抑郁症与痔疮疾病之间的双向因果关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Human Genomics GENETICS & HEREDITY-

CiteScore

6.00

自引率

2.20%

发文量

审稿时长

11 weeks

期刊介绍： Human Genomics is a peer-reviewed, open access, online journal that focuses on the application of genomic analysis in all aspects of human health and disease, as well as genomic analysis of drug efficacy and safety, and comparative genomics. Topics covered by the journal include, but are not limited to: pharmacogenomics, genome-wide association studies, genome-wide sequencing, exome sequencing, next-generation deep-sequencing, functional genomics, epigenomics, translational genomics, expression profiling, proteomics, bioinformatics, animal models, statistical genetics, genetic epidemiology, human population genetics and comparative genomics.