Evaluation of Optic Nerve Head Microcirculation in Open-Angle Glaucoma Patients with Unilateral Visual Field Defect.

IF 2 4区 医学 Q2 OPHTHALMOLOGY Ophthalmic Research Pub Date : 2024-01-01 Epub Date: 2024-03-20 DOI:10.1159/000538407
Pei-Wen Lin, Li-Wen Chiu
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Abstract

Introduction: Microcirculation of optic nerve head (ONH) in open-angle glaucoma (OAG) patients with unilateral visual field (VF) loss has yet to be fully investigated, especially the perimetrically unaffected fellow eyes.

Methods: Thirty-eight OAG patients with VF defect in one eye and normal VF in the other eye, and thirty-one healthy participants were analyzed. All participants underwent laser speckle flowgraphy (LSFG), spectral-domain optical coherence tomography (SD-OCT) imaging, and VF test for further analyses. LSFG measurements included mean blur rate in all area of ONH (MA), big vessel area of ONH (MV), and tissue area of ONH (MT). SD-OCT parameters included circumpapillary retinal nerve fiber layer (cpRNFL) thickness and macula thicknesses. The difference of LSFG and SD-OCT indices between glaucoma patients and healthy controls were compared. The diagnostic accuracy was analyzed with the areas under the receiver operating characteristic curves (AROCs).

Results: Global cpRNFL thickness and macular thickness in unaffected eyes of OAG patients were higher than their fellow eyes and lower than healthy eyes. MA and MV in healthy eyes and unaffected eyes were significantly higher than in affected eyes. MT in unaffected eyes of OAG patients was higher than in their fellow affected eyes but lower than in healthy eyes. The AROCs were highest for cpRNFL (0.925), followed by macular thickness (0.838), and MT (0.834).

Conclusions: ONH microcirculation in perimetrically unaffected fellow eyes was decreased in OAG patients with unilateral VF loss. LSFG can detect changes of ONH in high-risk eyes before detectable VF damage, which may reflect the vascular pathophysiology for glaucoma.

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评估单侧视野缺损的开角型青光眼患者的视神经头微循环。
导言:开角型青光眼(OAG)单侧视野(VF)缺失患者视神经头(ONH)的微循环尚未得到充分研究,尤其是未受影响的同侧眼的微循环:分析了 38 名单眼视野缺损、另一眼视野正常的 OAG 患者和 31 名健康参与者。所有参与者都接受了激光斑点血流成像(LSFG)、光谱域光学相干断层扫描(SD-OCT)成像和 VF 测试,以便进一步分析。LSFG测量包括视网膜上皮所有区域(MA)、视网膜上皮大血管区域(MV)和视网膜上皮组织区域(MT)的平均模糊率。SD-OCT 参数包括环毛细血管视网膜神经纤维层(cpRNFL)厚度和黄斑厚度。比较了青光眼患者和健康对照组之间 LSFG 和 SD-OCT 指数的差异。用接收者操作特征曲线下面积(AROCs)分析了诊断的准确性:结果:OAG 患者未受影响眼的整体 cpRNFL 厚度和黄斑厚度高于同侧眼,低于健康眼。健康眼和未受影响眼的 MA 和 MV 明显高于受影响眼。OAG 患者未受影响眼球的 MT 值高于同受影响眼球,但低于健康眼球。cpRNFL的AROC最高(0.925),其次是黄斑厚度(0.838)和MT(0.834):结论:单侧视力丧失的 OAG 患者周边未受影响的同侧眼的视网膜上皮微循环减少。LSFG能在检测到VF损伤之前检测到高危眼球的ONH变化,这可能反映了青光眼的血管病理生理学。
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来源期刊
Ophthalmic Research
Ophthalmic Research 医学-眼科学
CiteScore
3.80
自引率
4.80%
发文量
75
审稿时长
6-12 weeks
期刊介绍: ''Ophthalmic Research'' features original papers and reviews reporting on translational and clinical studies. Authors from throughout the world cover research topics on every field in connection with physical, physiologic, pharmacological, biochemical and molecular biological aspects of ophthalmology. This journal also aims to provide a record of international clinical research for both researchers and clinicians in ophthalmology. Finally, the transfer of information from fundamental research to clinical research and clinical practice is particularly welcome.
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