Quantifying partial volume effect in SPECT and planar imaging: optimizing region of interest for activity concentration estimation in different sphere sizes.

IF 1.3 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Nuclear Medicine Communications Pub Date : 2024-06-01 Epub Date: 2024-03-20 DOI:10.1097/MNM.0000000000001835
Mostafa Jalilifar, Mahdi Sadeghi, Alireza Emami-Ardekani, Kouhyar Geravand, Parham Geramifar
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Abstract

Introduction: To quantify the partial volume effect in single photon emission tomography (SPECT) and planar images of Carlson phantom as well as providing an optimum region of interest (ROI) required to more accurately estimate the activity concentration for different sphere sizes.

Methods: 131 I solution with the 161.16 kBq/ml concentration was uniformly filled into the different spheres of Carlson phantom (cold background condition) with the diameters of 7.3, 9.2, 11.4, 14.3, 17.9, 22.4 and 29.9 mm, and there was no background activity. In the hot background condition, the spheres were filled with the solution of 131 I with the 1276.5 kBq/ml addition to the background activity concentration of 161.16 kBq/ml in all the phantoms. The spheres were mounted inside the phantom and underwent SPECT and planar images. ROI was drawn closely on the boundary of each sphere image and it was extended to extract the true count.

Results: In the cold background condition, the recovery coefficient (RC) value for SPECT images ranged between 0.8 and 1.03. However, in planar imaging, the RC value was 0.72 for the smallest sphere size and it increased for larger spheres until 0.98 for 29.9 mm. In the hot background condition, the RC value for sphere diameters larger than 20 mm was overestimated more than in the cold background condition. The ROI/size required to more accurately determine activity concentration for the cold background ranged from 1.18 to 2.7. However, in the hot background condition, this ratio varied from 1.34 to 4.05.

Conclusion: In the quantification of partial volume effects, the spill-out effect seems to play a crucial role in the distribution of the image counts beyond the boundaries of the image pixels. However, more investigations are needed to accurately characterize limitations regarding the object size, background levels, and other factors.

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量化 SPECT 和平面成像中的部分容积效应:优化不同球体大小的活性浓度估算兴趣区。
简介量化单光子发射断层扫描(SPECT)和卡尔森模型平面图像中的部分体积效应,并提供一个最佳感兴趣区(ROI),以便更准确地估计不同球体大小的放射性浓度。方法:将浓度为 161.16 kBq/ml 的 131I 溶液均匀注入直径分别为 7.3、9.2、11.4、14.3、17.9、22.4 和 29.9 毫米的不同卡尔森模型球(冷背景条件)中,无背景活动。在热本底条件下,球体中充满了 131I 溶液,浓度为 1276.5 kBq/ml,所有模型中的本底活度浓度均为 161.16 kBq/ml。将球体安装在模型内,进行 SPECT 和平面成像。在每个球体图像的边界上绘制 ROI,并将其扩展以提取真实计数:结果:在冷背景条件下,SPECT 图像的恢复系数(RC)值介于 0.8 和 1.03 之间。然而,在平面成像中,最小球体尺寸的 RC 值为 0.72,球体尺寸越大,RC 值越高,29.9 毫米球体的 RC 值为 0.98。在热背景条件下,直径大于 20 毫米的球体的 RC 值比冷背景条件下高估得更多。在冷背景条件下,要更准确地确定放射性浓度,所需的 ROI/尺寸在 1.18 到 2.7 之间。然而,在热背景条件下,这一比率从 1.34 到 4.05 不等:在部分体积效应的量化中,溢出效应似乎在图像像素边界之外的图像计数分布中起着至关重要的作用。然而,还需要进行更多的研究,以准确描述物体大小、背景水平和其他因素的限制。
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来源期刊
CiteScore
2.20
自引率
6.70%
发文量
212
审稿时长
3-8 weeks
期刊介绍: Nuclear Medicine Communications, the official journal of the British Nuclear Medicine Society, is a rapid communications journal covering nuclear medicine and molecular imaging with radionuclides, and the basic supporting sciences. As well as clinical research and commentary, manuscripts describing research on preclinical and basic sciences (radiochemistry, radiopharmacy, radiobiology, radiopharmacology, medical physics, computing and engineering, and technical and nursing professions involved in delivering nuclear medicine services) are welcomed, as the journal is intended to be of interest internationally to all members of the many medical and non-medical disciplines involved in nuclear medicine. In addition to papers reporting original studies, frankly written editorials and topical reviews are a regular feature of the journal.
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