Preinterventional pan-immune-inflammation value as a tool to predict postcontrast acute kidney injury among acute coronary syndrome patients implanted drug-eluting stents: a retrospective observational study.

IF 1.3 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2024-04-01 Epub Date: 2024-03-20 DOI:10.1080/00365513.2024.2330904
Alparslan Kurtul, Murat Gok
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Abstract

We evaluated the value of pan-immune-inflammation value (PIV) in predicting the risk for postcontrast acute kidney injury (PCAKI), an important complication following percutaneous coronary intervention (PCI) in acute coronary syndrome (ACS) patients. Medical records of 839 ACS patients underwent PCI between June 2019 and December 2022 were retrospectively analyzed. Patients were divided into two groups: PCAKI (-) and PCAKI (+). PCAKI was defined as a ≥ 0.5 mg/dL and/or a ≥ 25% increase in serum creatinine within 72 h after PCI. The PIV was computed as [neutrophils × platelets × monocytes]÷lymphocytes. The mean age was 60.7 ± 12.9 years. PCAKI was detected in 105 (12.51%) patients. PIV was higher in the PCAKI (+) group compared to PCAKI (-) group (median 1150, interquartile range [IQR] 663-2021 vs median 366, IQR 238-527, p < 0.001). Receiver operating characteristic curve analysis showed that the best cutoff of PIV for predicting PCAKI was 576 with 81% sensitivity and 80% specificity. PIV was superior to neutrophil-lymphocyte ratio and platelet-lymphocyte ratio for the prediction of PCAKI (area under curve:0.894, 0.849 and 0.817, respectively, p < 0.001 for all). A high PIV was independently correlated with PCAKI (≤576 vs. >576, odds ratio [OR] 12.484, 95%confidence interval [CI] 4.853-32.118, p < 0.001) together with older age (OR 1.058, p = 0.009), female gender (OR 4.374, p = 0.005), active smoking (OR 0.193, p = 0.012), left ventricular ejection fraction (OR 0.954, p = 0.021), creatinine (OR 10.120, p < 0.001), hemoglobin (OR 0.759, p = 0.019) and c-reactive protein (OR 1.121, p = 0.002). In conclusion, a high PIV seems to be an easily assessable tool that can be used in clinical practice for predicting the risk of PCAKI in ACS patients implanted drug-eluting stents.

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将介入前泛免疫炎症值作为预测植入药物洗脱支架的急性冠脉综合征患者造影后急性肾损伤的工具:一项回顾性观察研究。
我们评估了泛免疫炎症值(PIV)在预测急性冠状动脉综合征(ACS)患者经皮冠状动脉介入治疗(PCI)后的重要并发症--造影后急性肾损伤(PCAKI)风险方面的价值。研究人员对2019年6月至2022年12月期间接受PCI治疗的839名ACS患者的病历进行了回顾性分析。患者被分为两组:PCAKI(-)组和PCAKI(+)组。PCAKI定义为PCI术后72小时内血清肌酐升高≥0.5 mg/dL和/或≥25%。PIV计算公式为[中性粒细胞×血小板×单核细胞]÷淋巴细胞。平均年龄为 60.7 ± 12.9 岁。105例(12.51%)患者检测到PCAKI。与 PCAKI (-) 组相比,PAKI (+) 组的 PIV 更高(中位数 1150,四分位数间距 [IQR] 663-2021 vs 中位数 366,IQR 238-527,p p 576,几率比 [OR] 12.484,95% 置信区间 [CI]4.853-32.118,p p = 0.009)、女性性别(OR 4.374,P = 0.005)、主动吸烟(OR 0.193,P = 0.012)、左室射血分数(OR 0.954,P = 0.021)、肌酐(OR 10.120,P = 0.019)和 c 反应蛋白(OR 1.121,P = 0.002)。总之,高 PIV 似乎是一种易于评估的工具,可在临床实践中用于预测植入药物洗脱支架的 ACS 患者发生 PCAKI 的风险。
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来源期刊
CiteScore
3.50
自引率
4.80%
发文量
85
审稿时长
4-8 weeks
期刊介绍: The Scandinavian Journal of Clinical and Laboratory Investigation is an international scientific journal covering clinically oriented biochemical and physiological research. Since the launch of the journal in 1949, it has been a forum for international laboratory medicine, closely related to, and edited by, The Scandinavian Society for Clinical Chemistry. The journal contains peer-reviewed articles, editorials, invited reviews, and short technical notes, as well as several supplements each year. Supplements consist of monographs, and symposium and congress reports covering subjects within clinical chemistry and clinical physiology.
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