Hypertensive states of pregnancy

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-04-01 DOI:10.1016/j.hipert.2023.11.006

E. Rubio Gonzalez , A.M. Huerta Arroyo , F. Garcia Benasach , T. Gijon Conde

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Abstract

Hypertensive disorders in pregnancy (HDP) remain a leading cause of pregnancy-related maternal and foetal morbidity and mortality worldwide, including chronic hypertension, gestational hypertension, and pre-eclampsia.

Affected women and newborns also have an increased risk of cardiovascular disease later in life, independent of traditional cardiovascular disease risks. Despite these risks, recommendations for optimal diagnosis and treatment have changed little in recent decades, probably due to fear of the foetal repercussions of decreased blood pressure and possible drug toxicity.

In this document we review the diagnostic criteria and classification of (HDP), as well as important aspects regarding pathophysiology and early detection that allows early identification of women at risk, with the aim of preventing both immediate and long-term consequences. Prophylactic treatment with aspirin is also reviewed early and a therapeutic approach is carried out that involves close maternal and foetal monitoring, and if necessary, the use of safe drugs in each situation.

This review aims to provide an updated vision for the prevention, diagnosis, and treatment of HDP that is useful in our usual clinical practice.

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妊娠高血压状态。

妊娠期高血压疾病（HDP）仍然是全世界与妊娠有关的孕产妇和胎儿发病率和死亡率的主要原因，包括慢性高血压、妊娠高血压和先兆子痫。受影响的妇女和新生儿日后罹患心血管疾病的风险也会增加，这与传统的心血管疾病风险无关。尽管存在这些风险，但可能是由于担心血压下降对胎儿的影响以及可能的药物毒性，近几十年来有关最佳诊断和治疗的建议几乎没有改变。在本文件中，我们回顾了（HDP）的诊断标准和分类，以及有关病理生理学和早期检测的重要方面，以便及早发现有风险的妇女，从而预防直接和长期的后果。此外，还对阿司匹林的预防性治疗进行了早期审查，并采取了一种治疗方法，包括对产妇和胎儿进行密切监测，必要时在各种情况下使用安全药物。本综述旨在为 HDP 的预防、诊断和治疗提供最新的视角，以便在我们的日常临床实践中发挥作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.