Dilation of ion selectivity filters in cation channels

IF 11.6 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Trends in Biochemical Sciences Pub Date : 2024-05-01 DOI:10.1016/j.tibs.2024.02.004
Kate Huffer , Xiao-Feng Tan , Ana I. Fernández-Mariño , Surbhi Dhingra , Kenton J. Swartz
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Abstract

Ion channels establish the voltage gradient across cellular membranes by providing aqueous pathways for ions to selectively diffuse down their concentration gradients. The selectivity of any given channel for its favored ions has conventionally been viewed as a stable property, and in many cation channels, it is determined by an ion-selectivity filter within the external end of the ion-permeation pathway. In several instances, including voltage-activated K+ (Kv) channels, ATP-activated P2X receptor channels, and transient receptor potential (TRP) channels, the ion-permeation pathways have been proposed to dilate in response to persistent activation, dynamically altering ion permeation. Here, we discuss evidence for dynamic ion selectivity, examples where ion selectivity filters exhibit structural plasticity, and opportunities to fill gaps in our current understanding.

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阳离子通道中离子选择性过滤器的扩张。
离子通道通过为离子提供沿着浓度梯度选择性扩散的水通道,在细胞膜上形成电压梯度。任何特定通道对其偏爱离子的选择性通常被视为一种稳定的特性,在许多阳离子通道中,它是由离子渗透途径外部端的离子选择性过滤器决定的。在一些情况下,包括电压激活的 K+ (Kv) 通道、ATP 激活的 P2X 受体通道和瞬时受体电位(TRP)通道,离子渗透途径被认为会随着持续激活而扩张,从而动态地改变离子渗透。在此,我们将讨论动态离子选择性的证据、离子选择性过滤器表现出结构可塑性的例子,以及填补我们目前认识空白的机会。
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来源期刊
Trends in Biochemical Sciences
Trends in Biochemical Sciences 生物-生化与分子生物学
CiteScore
22.90
自引率
0.70%
发文量
148
审稿时长
6-12 weeks
期刊介绍: For over 40 years, Trends in Biochemical Sciences (TIBS) has been a leading publication keeping readers informed about recent advances in all areas of biochemistry and molecular biology. Through monthly, peer-reviewed issues, TIBS covers a wide range of topics, from traditional subjects like protein structure and function to emerging areas in signaling and metabolism. Articles are curated by the Editor and authored by top researchers in their fields, with a focus on moving beyond simple literature summaries to providing novel insights and perspectives. Each issue primarily features concise and timely Reviews and Opinions, supplemented by shorter articles including Spotlights, Forums, and Technology of the Month, as well as impactful pieces like Science & Society and Scientific Life articles.
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