Effects of Ninjurin 2 polymorphisms on susceptibility to coronary heart disease.

IF 3.4 3区生物学 Q3 CELL BIOLOGY Cell Cycle Pub Date : 2024-02-01 Epub Date: 2024-03-21 DOI:10.1080/15384101.2024.2330225

Yuping Yan, Xiaoyan Du, Xia Dou, Jingjie Li, Wenjie Zhang, Shuangyu Yang, Wenting Meng, Gang Tian

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Abstract

Objective: The aim of this study was to explore the effects of Ninjurin 2 (NINJ2) polymorphisms on susceptibility to coronary heart disease (CHD).

Methods: We conducted a case-control study with 499 CHD cases and 505 age and gender-matched controls. Five single nucleotide polymorphisms (SNPs) in NINJ2 (rs118050317, rs75750647, rs7307242, rs10849390, and rs11610368) were genotyped by the Agena MassARRAY platform. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using logistic regression analysis to assess the association of NINJ2 polymorphisms and CHD risk-adjusted for age and gender. What's more, risk genes and molecular functions were screened via protein-protein interaction (PPI) network and functional enrichment analysis.

Results: Rs118050317 in NINJ2 significantly increased CHD risk in people aged more than 60 years and women. Rs118050317 and rs7307242 had strong relationships with hypertension risk in CHD patients. Additionally, rs75750647 exceedingly raised diabetes risk in cases under multiple models, whereas rs10849390 could protect CHD patients from diabetes in allele, homozygote, and additive models. We also observed two blocks in NINJ2. Further interaction network and enrichment analysis showed that NINJ2 played a greater role in the pathogenesis and progression of CHD.

Conclusion: Our results suggest that NINJ2 polymorphisms are associated with CHD risk.

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Ninjurin 2 多态性对冠心病易感性的影响。

研究目的本研究旨在探讨 Ninjurin 2（NINJ2）多态性对冠心病（CHD）易感性的影响：我们对 499 例冠心病病例和 505 例年龄与性别匹配的对照组进行了病例对照研究。通过 Agena MassARRAY 平台对 NINJ2 中的五个单核苷酸多态性（SNPs）（rs118050317、rs75750647、rs7307242、rs10849390 和 rs11610368）进行了基因分型。通过逻辑回归分析计算出了比值比（ORs）和95%置信区间（CIs），以评估NINJ2多态性与冠心病风险的相关性，并对年龄和性别进行了调整。此外，还通过蛋白相互作用（PPI）网络和功能富集分析筛选了风险基因和分子功能：结果发现：NINJ2中的Rs118050317显著增加了60岁以上人群和女性患冠心病的风险。Rs118050317 和 rs7307242 与心脏病患者的高血压风险有密切关系。此外，在多重模型下，rs75750647 可使糖尿病风险超常升高，而在等位基因、同基因和加性模型中，rs10849390 可保护冠心病患者免于糖尿病。我们还在 NINJ2 中观察到两个区块。进一步的相互作用网络和富集分析表明，NINJ2在CHD的发病和进展中发挥着更大的作用：我们的研究结果表明，NINJ2 多态性与冠心病风险有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Cycle 生物-细胞生物学

CiteScore

7.70

自引率

2.30%

发文量

281

审稿时长

1 months

期刊介绍： Cell Cycle is a bi-weekly peer-reviewed journal of high priority research from all areas of cell biology. Cell Cycle covers all topics from yeast to man, from DNA to function, from development to aging, from stem cells to cell senescence, from metabolism to cell death, from cancer to neurobiology, from molecular biology to therapeutics. Our goal is fast publication of outstanding research.