Clinicopathological and endoscopic features of Helicobacter pylori infection-negative gastric cancer in Japan: a retrospective study.

IF 2.1 Q3 GASTROENTEROLOGY & HEPATOLOGY Clinical Endoscopy Pub Date : 2024-07-01 Epub Date: 2024-03-22 DOI:10.5946/ce.2023.258

Kentaro Imamura, Kenshi Yao, Satoshi Nimura, Takao Kanemitsu, Masaki Miyaoka, Yoichiro Ono, Toshiharu Ueki, Hiroshi Tanabe

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Abstract

Background/aims: Helicobacter pylori infection-negative gastric cancer (HPNGC) has not been systematically investigated in consecutive patients. Hence, this study aimed to investigate the clinicopathological and endoscopic features of HPNGC.

Methods: This single-center retrospective study selected participants from patients with gastric cancer who were treated at the Fukuoka University Chikushi Hospital between January 2013 and December 2021. Only patients diagnosed with HPNGC were enrolled, and their clinicopathological and endoscopic features were analyzed in detail.

Results: The prevalence of HPNGC in the present study was 2.6% (54/2112). The types of HPNGC observed in each gastric region were as follows: advanced gastric cancer was observed in the cardia; gastric adenocarcinoma of fundic-gland differentiation, gastric adenocarcinoma of foveolar-type presenting with whitish elevation and raspberry-like foveolar-type gastric adenocarcinoma, gastric adenocarcinoma arising in polyposis, and gastric adenocarcinoma with autoimmune gastritis were observed in the fundic gland region ranging from the gastric fornix to the gastric body; signet-ring cell carcinoma was observed in the gastric-pyloric transition region ranging from the lower gastric body to the gastric angle; and well-differentiated tubular adenocarcinoma with low-grade atypia was observed in the antrum.

Conclusions: This study revealed that tumors from each gastric region exhibited distinct macroscopic and histological types in HPNGC.

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日本幽门螺杆菌感染阴性胃癌的临床病理和内镜特征：一项回顾性研究。

背景/目的：幽门螺杆菌感染阴性胃癌（HPNGC）尚未在连续患者中进行系统研究。因此，本研究旨在调查 HPNGC 的临床病理和内镜特征：这项单中心回顾性研究选取了 2013 年 1 月至 2021 年 12 月期间在福冈大学筑紫医院接受治疗的胃癌患者。只有确诊为 HPNGC 的患者才被纳入研究，并详细分析了他们的临床病理和内镜特征：本研究中 HPNGC 的发病率为 2.6%（54/2112）。在各胃区观察到的 HPNGC 类型如下：在贲门部观察到晚期胃癌；在从胃穹窿到胃体的胃底腺区域观察到基底腺分化型胃腺癌、表现为白色隆起的蜂窝型胃腺癌和覆盆子样蜂窝型胃腺癌、息肉病引起的胃腺癌以及伴有自身免疫性胃炎的胃腺癌；在胃体下部至胃角的胃幽门过渡区观察到标志环细胞癌；在胃窦观察到低度不典型的分化良好的管状腺癌。结论这项研究表明，在 HPNGC 中，每个胃区的肿瘤都表现出不同的宏观和组织学类型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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