The Impact of microRNA SNPs on Breast Cancer: Potential Biomarkers for Disease Detection.

IF 2.4 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Molecular Biotechnology Pub Date : 2025-03-01 Epub Date: 2024-03-21 DOI:10.1007/s12033-024-01113-w

Sakshi Chauhan, Runjhun Mathur, Abhimanyu Kumar Jha

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Abstract

Breast cancer is considered a significant health concern worldwide, with genetic predisposition playing a critical role in its etiology. Single nucleotide polymorphisms (SNPs), particularly those within the 3' untranslated regions (3'UTRs) of target genes, are emerging as key factors in breast cancer susceptibility. Specifically, miRNAs have been recognized as possible novel approach for biomarkers discovery for both prognosis and diagnosis due to their direct association with cancer progression. Regional disparities in breast cancer incidence underscore the need for precise interventions, considering socio-cultural and economic factors. This review explores into the differential effects of SNP-miRNA interactions on breast cancer risk, emphasizing both risk-enhancing and protective associations across diverse populations. Furthermore, it explores the clinical implications of these findings, highlighting the potential of personalized approaches in breast cancer management. Additionally, it reviews the evolving therapeutic prospect of microRNAs (miRNAs), extending beyond cancer therapeutics to encompass various diseases, indicative of their versatility as therapeutic agents.

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微RNA SNPS对乳腺癌的影响：疾病检测的潜在生物标记物

乳腺癌被认为是全球关注的重大健康问题，而遗传易感性在其病因中起着至关重要的作用。单核苷酸多态性（SNPs），尤其是靶基因 3' 非翻译区（3'UTRs）内的单核苷酸多态性，正在成为乳腺癌易感性的关键因素。特别是 miRNA，由于其与癌症进展直接相关，已被认为是发现预后和诊断生物标志物的新方法。考虑到社会文化和经济因素，乳腺癌发病率的地区差异凸显了精确干预的必要性。本综述探讨了 SNP-miRNA 相互作用对乳腺癌风险的不同影响，强调了不同人群中的风险增强和保护性关联。此外，它还探讨了这些发现的临床意义，强调了个性化方法在乳腺癌管理中的潜力。此外，它还回顾了微小核糖核酸（miRNA）不断发展的治疗前景，从癌症治疗扩展到各种疾病，表明了它们作为治疗剂的多功能性。

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来源期刊

Molecular Biotechnology 医学-生化与分子生物学

CiteScore

4.10

自引率

3.80%

发文量

165

审稿时长

6 months

期刊介绍： Molecular Biotechnology publishes original research papers on the application of molecular biology to both basic and applied research in the field of biotechnology. Particular areas of interest include the following: stability and expression of cloned gene products, cell transformation, gene cloning systems and the production of recombinant proteins, protein purification and analysis, transgenic species, developmental biology, mutation analysis, the applications of DNA fingerprinting, RNA interference, and PCR technology, microarray technology, proteomics, mass spectrometry, bioinformatics, plant molecular biology, microbial genetics, gene probes and the diagnosis of disease, pharmaceutical and health care products, therapeutic agents, vaccines, gene targeting, gene therapy, stem cell technology and tissue engineering, antisense technology, protein engineering and enzyme technology, monoclonal antibodies, glycobiology and glycomics, and agricultural biotechnology.