Extracellular vesicles derived from mesenchymal stem cells: the wine in Hebe's hands to treat skin aging.

IF 5.1 4区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Precision Clinical Medicine Pub Date : 2024-02-24 eCollection Date: 2024-03-01 DOI:10.1093/pcmedi/pbae004

Qixiang Gui, Neng Ding, Zuochao Yao, Minjuan Wu, Ruifeng Fu, Yue Wang, Yunpeng Zhao, Lie Zhu

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Abstract

Owing to its constant exposure to the external environment and various stimuli, skin ranks among the organs most vulnerable to manifestations of aging. Preventing and delaying skin aging has become one of the prominent research subjects in recent years. Mesenchymal stem cells (MSCs) are multipotent stem cells derived from mesoderm with high self-renewal ability and multilineage differentiation potential. MSC-derived extracellular vesicles (MSC-EVs) are nanoscale biological vesicles that facilitate intercellular communication and regulate biological behavior. Recent studies have shown that MSC-EVs have potential applications in anti-aging therapy due to their anti-inflammatory, anti-oxidative stress, and wound healing promoting abilities. This review presents the latest progress of MSC-EVs in delaying skin aging. It mainly includes the MSC-EVs promoting the proliferation and migration of keratinocytes and fibroblasts, reducing the expression of matrix metalloproteinases, resisting oxidative stress, and regulating inflammation. We then briefly discuss the recently discovered treatment methods of MSC-EVs in the field of skin anti-aging. Moreover, the advantages and limitations of EV-based treatments are also presented.

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源自间充质干细胞的细胞外囊泡：Hebe手中治疗皮肤老化的美酒。

由于经常暴露在外部环境和各种刺激下，皮肤是最容易出现衰老表现的器官之一。预防和延缓皮肤衰老已成为近年来的重要研究课题之一。间充质干细胞（MSCs）是一种多能干细胞，来源于中胚层，具有很强的自我更新能力和多线分化潜能。间充质干细胞衍生的细胞外囊泡（MSC-EVs）是一种纳米级生物囊泡，可促进细胞间的交流并调节生物行为。最近的研究表明，间充质干细胞胞外小泡具有抗炎、抗氧化应激和促进伤口愈合的能力，因此在抗衰老治疗中具有潜在的应用前景。本综述介绍了间充质干细胞-EV 在延缓皮肤衰老方面的最新进展。它主要包括间充质干细胞-EV促进角质形成细胞和成纤维细胞的增殖和迁移、减少基质金属蛋白酶的表达、抗氧化应激和调节炎症。然后，我们简要讨论了最近发现的间充质干细胞-EVs 在皮肤抗衰老领域的治疗方法。此外，我们还介绍了基于间充质干细胞-EV 的治疗方法的优势和局限性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Precision Clinical Medicine MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

10.80

自引率

0.00%

发文量

审稿时长

5 weeks

期刊介绍： Precision Clinical Medicine (PCM) is an international, peer-reviewed, open access journal that provides timely publication of original research articles, case reports, reviews, editorials, and perspectives across the spectrum of precision medicine. The journal's mission is to deliver new theories, methods, and evidence that enhance disease diagnosis, treatment, prevention, and prognosis, thereby establishing a vital communication platform for clinicians and researchers that has the potential to transform medical practice. PCM encompasses all facets of precision medicine, which involves personalized approaches to diagnosis, treatment, and prevention, tailored to individual patients or patient subgroups based on their unique genetic, phenotypic, or psychosocial profiles. The clinical conditions addressed by the journal include a wide range of areas such as cancer, infectious diseases, inherited diseases, complex diseases, and rare diseases.