Longitudinal Biochemical and Behavioral Alterations in a Gyrencephalic Model of Blast-Related Mild Traumatic Brain Injury.

IF 1.8 Q3 CLINICAL NEUROLOGY Neurotrauma reports Pub Date : 2024-03-14 eCollection Date: 2024-01-01 DOI:10.1089/neur.2024.0002
Shiyu Tang, Su Xu, Donna Wilder, Alexandre E Medina, Xin Li, Gary M Fiskum, Li Jiang, Venkata R Kakulavarapu, Joseph B Long, Rao P Gullapalli, Venkatasivasai Sujith Sajja
{"title":"Longitudinal Biochemical and Behavioral Alterations in a Gyrencephalic Model of Blast-Related Mild Traumatic Brain Injury.","authors":"Shiyu Tang, Su Xu, Donna Wilder, Alexandre E Medina, Xin Li, Gary M Fiskum, Li Jiang, Venkata R Kakulavarapu, Joseph B Long, Rao P Gullapalli, Venkatasivasai Sujith Sajja","doi":"10.1089/neur.2024.0002","DOIUrl":null,"url":null,"abstract":"<p><p>Blast-related traumatic brain injury (bTBI) is a major cause of neurological disorders in the U.S. military that can adversely impact some civilian populations as well and can lead to lifelong deficits and diminished quality of life. Among these types of injuries, the long-term sequelae are poorly understood because of variability in intensity and number of the blast exposure, as well as the range of subsequent symptoms that can overlap with those resulting from other traumatic events (e.g., post-traumatic stress disorder). Despite the valuable insights that rodent models have provided, there is a growing interest in using injury models using species with neuroanatomical features that more closely resemble the human brain. With this purpose, we established a gyrencephalic model of blast injury in ferrets, which underwent blast exposure applying conditions that closely mimic those associated with primary blast injuries to warfighters. In this study, we evaluated brain biochemical, microstructural, and behavioral profiles after blast exposure using <i>in vivo</i> longitudinal magnetic resonance imaging, histology, and behavioral assessments. In ferrets subjected to blast, the following alterations were found: 1) heightened impulsivity in decision making associated with pre-frontal cortex/amygdalar axis dysfunction; 2) transiently increased glutamate levels that are consistent with earlier findings during subacute stages post-TBI and may be involved in concomitant behavioral deficits; 3) abnormally high brain <i>N</i>-acetylaspartate levels that potentially reveal disrupted lipid synthesis and/or energy metabolism; and 4) dysfunction of pre-frontal cortex/auditory cortex signaling cascades that may reflect similar perturbations underlying secondary psychiatric disorders observed in warfighters after blast exposure.</p>","PeriodicalId":74300,"journal":{"name":"Neurotrauma reports","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10956534/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurotrauma reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1089/neur.2024.0002","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Blast-related traumatic brain injury (bTBI) is a major cause of neurological disorders in the U.S. military that can adversely impact some civilian populations as well and can lead to lifelong deficits and diminished quality of life. Among these types of injuries, the long-term sequelae are poorly understood because of variability in intensity and number of the blast exposure, as well as the range of subsequent symptoms that can overlap with those resulting from other traumatic events (e.g., post-traumatic stress disorder). Despite the valuable insights that rodent models have provided, there is a growing interest in using injury models using species with neuroanatomical features that more closely resemble the human brain. With this purpose, we established a gyrencephalic model of blast injury in ferrets, which underwent blast exposure applying conditions that closely mimic those associated with primary blast injuries to warfighters. In this study, we evaluated brain biochemical, microstructural, and behavioral profiles after blast exposure using in vivo longitudinal magnetic resonance imaging, histology, and behavioral assessments. In ferrets subjected to blast, the following alterations were found: 1) heightened impulsivity in decision making associated with pre-frontal cortex/amygdalar axis dysfunction; 2) transiently increased glutamate levels that are consistent with earlier findings during subacute stages post-TBI and may be involved in concomitant behavioral deficits; 3) abnormally high brain N-acetylaspartate levels that potentially reveal disrupted lipid synthesis and/or energy metabolism; and 4) dysfunction of pre-frontal cortex/auditory cortex signaling cascades that may reflect similar perturbations underlying secondary psychiatric disorders observed in warfighters after blast exposure.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
爆炸所致轻度脑损伤颅脑模型的纵向生化和行为改变
爆炸相关创伤性脑损伤(bTBI)是美军神经系统疾病的一个主要原因,也会对一些平民造成不利影响,并可能导致终生功能障碍和生活质量下降。在这些类型的伤害中,人们对长期后遗症的了解甚少,因为爆炸暴露的强度和次数各不相同,而且随后出现的一系列症状可能与其他创伤事件(如创伤后应激障碍)导致的症状重叠。尽管啮齿类动物模型提供了宝贵的见解,但人们对使用具有更接近人脑的神经解剖学特征的物种来建立损伤模型的兴趣与日俱增。为此,我们建立了雪貂脑爆炸损伤模型,雪貂会在与作战人员原发性爆炸损伤十分相似的条件下接受爆炸暴露。在这项研究中,我们使用体内纵向磁共振成像、组织学和行为评估方法,对遭受爆炸后的大脑生化、微观结构和行为特征进行了评估。在遭受爆炸的雪貂身上发现了以下变化:1) 与前额叶皮质/杏仁轴功能障碍有关的决策冲动性增强;2) 谷氨酸水平短暂升高,这与早先在创伤后亚急性阶段的发现一致,并可能与伴随的行为缺陷有关;3) 脑内 N-乙酰天冬氨酸水平异常升高,可能显示脂质合成和/或能量代谢紊乱;以及 4) 前额叶皮层/听觉皮层信号级联功能障碍,可能反映了在爆炸暴露后的战斗人员中观察到的继发性精神障碍的类似扰动。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
2.40
自引率
0.00%
发文量
0
审稿时长
8 weeks
期刊最新文献
Small Molecule Drug C381 Attenuates Brain Vascular Damage Following Repetitive Mild Traumatic Injury. Clinical Impact of an AI Decision Support System for Detection of Intracranial Hemorrhage in CT Scans. Metacognitive Therapy for People Experiencing Persistent Post-Concussion Symptoms Following Mild Traumatic Brain Injury: A Preliminary Multiple Case-Series Study. Multicenter Study Examining Temporal Trends in Traumatic Intracranial Hemorrhage Over Six Years Using Joinpoint Regression. Resilience and Concussion Recovery in Minority Women: Promoting Health Equity.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1