Johana Escudero-Cabarcas, Wilmar Pineda-Alhucema, Martha Martinez-Banfi, Johan E Acosta-López, Martha L Cervantes-Henriquez, Elsy Mejía-Segura, Giomar Jiménez-Figueroa, Cristian Sánchez-Barros, Pedro J Puentes-Rozo, Luz M Noguera-Machacón, Mostapha Ahmad, Moisés de la Hoz, Jorge I Vélez, Mauricio Arcos-Burgos, David A Pineda, Manuel Sánchez
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引用次数: 0
Abstract
Background: People with Huntington's disease (HD) exhibit neurocognitive alterations throughout the disease, including deficits in social cognitive processes such as Theory of Mind (ToM).
Objective: The aim is to identify methodologies and ToM instruments employed in HD, alongside relevant findings, within the scientific literature of the past two decades.
Methods: We conducted a comprehensive search for relevant papers in the SCOPUS, PubMed, APA-PsyArticles, Web of Science, Redalyc, and SciELO databases. In the selection process, we specifically focused on studies that included individuals with a confirmed genetic status of HD and investigated ToM functioning in patients with and without motor symptoms. The systematic review followed the PRISMA protocol.
Results: A total of 27 papers were selected for this systematic review, covering the period from 2003 to 2023. The findings consistently indicate that ToM is globally affected in patients with manifest motor symptoms. In individuals without motor symptoms, impairments are focused on the affective dimensions of ToM.
Conclusions: Based on our analysis, affective ToM could be considered a potential biomarker for HD. Therefore, it is recommended that ToM assessment be included as part of neuropsychological evaluation protocols in clinical settings. Suchinclusion could aid in the identification of early stages of the disease and provide new opportunities for treatment, particularly with emerging drugs like antisense oligomers. The Prospero registration number for this review is CRD42020209769.
背景：亨廷顿氏症（Huntington's disease，HD）患者在整个疾病过程中都会表现出神经认知的改变，包括心智理论（Theory of Mind，ToM）等社会认知过程的缺陷：目的：在过去二十年的科学文献中，确定在 HD 中使用的方法和 ToM 工具，以及相关的研究结果：我们在 SCOPUS、PubMed、APA-PsyArticles、Web of Science、Redalyc 和 SciELO 数据库中对相关论文进行了全面检索。在筛选过程中，我们特别关注那些包含已确诊的 HD 遗传状态的个体，以及调查有运动症状和无运动症状患者 ToM 功能的研究。系统性综述遵循了 PRISMA 协议：本系统综述共选取了 27 篇论文，时间跨度为 2003 年至 2023 年。研究结果一致表明，有明显运动症状的患者的 ToM 会受到全面影响。在没有运动症状的患者中，影响主要集中在 ToM 的情感层面：根据我们的分析，情感性 ToM 可被视为 HD 的潜在生物标志物。因此，建议将 ToM 评估纳入临床神经心理学评估方案。这种评估有助于识别疾病的早期阶段，并为治疗提供新的机会，特别是使用反义寡聚物等新兴药物。本综述的 Prospero 注册号为 CRD42020209769。
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