Reference values of parathyroid hormone in very low birth weight infants.

IF 2.1 4区医学 Q3 MEDICAL LABORATORY TECHNOLOGY Annals of Clinical Biochemistry Pub Date : 2024-09-01 Epub Date: 2024-04-06 DOI:10.1177/00045632241245942

Tomas Matejek, Bara Zapletalova, Jaroslav Stranik, Lenka Zaloudkova, Vladimir Palicka

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Abstract

Purpose: The primary goal was to estimate reference values of parathyroid hormone (PTH) in very low birth weight infants without severe neonatal morbidity. A secondary objective was to assess the relationship between PTH serum levels and selected laboratory markers of bone metabolism.

Methods: Ninety two infants with birth weight less than 1500 g met the inclusion criteria of the study. Serum levels of PTH, 25-hydroxyvitamin-D [25(OH)D], C3-epi-25(OH)D, total calcium, phosphorus, and alkaline phosphatase, and urinary levels of calcium, phosphorus, and creatinine were examined on day 14 and subsequently every 2 weeks until discharge.

Results: Of the total 167 serum samples examined for PTH levels in infants without 25(OH)D deficiency the estimated range was 0.9-11.9 pmol/l (8.5-112.3 pg/mL). During the first month, no statistically significant correlation was observed between PTH level and that of 25(OH)D, C3-epimers of 25(OH)D, S-Ca, S-P, or ALP, nor with urinary excretion of calcium and phosphorus. From the second month of life, there was a moderately significant correlation between PTH and 25(OH)D (Rho = -0.40, P =< .001), between PTH and calcium/creatinine ratio (Rho = -0.56, P = < .001), and between PTH and phosphorus/creatinine ratio (Rho = 0.51, P = < .001).

Conclusions: The physiological range for PTH levels for preterm neonates without 25(OH)D deficiency was estimated as 0.9-11.9 pmol/l (8.5-112.3 pg/mL). It seems that elevation of serum PTH above this range can be considered as hyperparathyroidism in very low birth weight infants.

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超低出生体重儿甲状旁腺激素的参考值。

目的：首要目标是估算无严重新生儿疾病的极低出生体重儿的甲状旁腺激素（PTH）参考值。次要目标是评估 PTH 血清水平与选定的骨代谢实验室指标之间的关系。方法：92 名出生体重小于 1500 克的婴儿符合研究的纳入标准。第 14 天检测血清中的 PTH、25-羟基维生素-D [25(OH)D]、C3-表-25(OH)D、总钙、磷和碱性磷酸酶水平，以及尿液中的钙、磷和肌酐水平，随后每两周检测一次，直至出院：在检测的 167 份血清样本中，无 25(OH)D 缺乏症的婴儿的 PTH 水平估计范围为 0.9 - 11.9 pmol/l（8.5 - 112.3 pg/ml）。在出生后的第一个月，PTH 水平与 25（OH）D、25（OH）D 的 C3-表聚物、S-Ca、S-P 或 ALP 的水平以及尿液中钙和磷的排泄量之间没有明显的统计学相关性。从出生后第二个月开始，PTH 和 25（OH）D 之间存在中度相关性（Rho = -0.40，p =结论：没有 25（OH）D 缺乏症的早产新生儿 PTH 水平的生理范围估计为 0.9 - 11.9 pmol/l（8.5 - 112.3 pg/ml）。在极低出生体重儿中，血清 PTH 升高超过这一范围似乎可视为甲状旁腺功能亢进。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Clinical Biochemistry Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry

CiteScore

5.20

自引率

4.50%

发文量

期刊介绍： Annals of Clinical Biochemistry is the fully peer reviewed international journal of the Association for Clinical Biochemistry and Laboratory Medicine. Annals of Clinical Biochemistry accepts papers that contribute to knowledge in all fields of laboratory medicine, especially those pertaining to the understanding, diagnosis and treatment of human disease. It publishes papers on clinical biochemistry, clinical audit, metabolic medicine, immunology, genetics, biotechnology, haematology, microbiology, computing and management where they have both biochemical and clinical relevance. Papers describing evaluation or implementation of commercial reagent kits or the performance of new analysers require substantial original information. Unless of exceptional interest and novelty, studies dealing with the redox status in various diseases are not generally considered within the journal''s scope. Studies documenting the association of single nucleotide polymorphisms (SNPs) with particular phenotypes will not normally be considered, given the greater strength of genome wide association studies (GWAS). Research undertaken in non-human animals will not be considered for publication in the Annals. Annals of Clinical Biochemistry is also the official journal of NVKC (de Nederlandse Vereniging voor Klinische Chemie) and JSCC (Japan Society of Clinical Chemistry).