Enzymatic kinetic resolution of an intermediate alcohol of the drug Tegoprazan using lipase from Thermomyces lanuginosus

IF 1.4 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Biocatalysis and Biotransformation Pub Date : 2024-03-21 DOI:10.1080/10242422.2024.2326421
Deepthi Pulivarthi, Ravinder Reddy Patlolla, Joshna Kuni, Raveena Gajjala, Santhosh Nayak Kethavath, Linga Banoth, Subba Reddy B V
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Abstract

An enzymatic approach for the synthesis of intermediate alcohol of the drug tegoprazan in 99% ee at 20 °C in hexane has been developed utilizing commercially available immobilized Thermomyces lanug...
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来源期刊
Biocatalysis and Biotransformation
Biocatalysis and Biotransformation 生物-生化与分子生物学
CiteScore
4.40
自引率
5.60%
发文量
37
审稿时长
3 months
期刊介绍: Biocatalysis and Biotransformation publishes high quality research on the application of biological catalysts for the synthesis, interconversion or degradation of chemical species. Papers are published in the areas of: Mechanistic principles Kinetics and thermodynamics of biocatalytic processes Chemical or genetic modification of biocatalysts Developments in biocatalyst''s immobilization Activity and stability of biocatalysts in non-aqueous and multi-phasic environments, including the design of large scale biocatalytic processes Biomimetic systems Environmental applications of biocatalysis Metabolic engineering Types of articles published are; full-length original research articles, reviews, short communications on the application of biotransformations, and preliminary reports of novel catalytic activities.
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