Fish and Shellfish Consumption, Cognitive Health and Mortality from Alzheimer’s Disease among US Adults Aged 60 and Older

IF 4.3 Q2 BUSINESS The Journal of Prevention of Alzheimer's Disease Pub Date : 2024-03-11 DOI:10.14283/jpad.2024.57

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Abstract

Background

Relationships of fish-shellfish consumption, cognitive health and mortality from Alzheimer’s disease (AD) among US adults aged 60 years and older have not been adequately studied.

Objectives

To determine the relationship of fish-shellfish consumption, cognitive health and mortality from AD in US adults aged 60 years and older.

Design, Setting and Participants

The data of this cross-sectional study of US adults aged 60 years and older were from the National Nutrition and Health Examination Survey (NHANES) datasets. Frequency of fish-shellfish consumption, its association with subjective cognitive decline (SCD) and AD mortality of these participants between 1999 and 2018 and cognitive assessment scores between 2011 and 2014 were analyzed.

Measurements and Results

US adults aged 60 years and older consumed fish-shellfish 1.2 times/week and had a blood Hg of 1.63 ug/L on average between 1999 and 2018. Participants aged 60 years and older in the highest quartile of fish-shellfish consumption (∼3 times/week) had significantly higher cognitive assessment scores than those in the lowest quartile (rare or no fish-shellfish consumption). Adults in the highest quartile of fish-shellfish consumption had a 30% lower risk (odds ratio 0.7, 95%CI 0.57–0.87) of SCD, and 44% lower risk (hazard ratio 0.56, 95%CI 0.35–0.9) of AD mortality than those in the lowest quartile.

Conclusion

Increased fish-shellfish consumption was associated with improved scores of cognitive assessment and reduced risks of SCD and AD mortality.

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美国 60 岁及以上成年人的鱼类和贝类摄入量、认知健康和阿尔茨海默病死亡率

摘要背景尚未对美国 60 岁及以上成年人食用鱼类贝类、认知健康和阿尔茨海默病（AD）死亡率之间的关系进行充分研究。目的确定美国 60 岁及以上成年人食用鱼类贝类、认知健康和阿尔茨海默病死亡率之间的关系。设计、地点和参与者这项横断面研究的数据来自美国国家营养与健康调查（NHANES）数据集，研究对象为美国 60 岁及以上的成年人。研究分析了这些参与者在 1999 年至 2018 年期间食用鱼类-贝类的频率、其与主观认知能力下降（SCD）和注意力缺失症死亡率的关系，以及 2011 年至 2014 年期间的认知评估得分。测量和结果美国 60 岁及以上的成年人在 1999 年至 2018 年间平均每周食用 1.2 次鱼介贝类，血液中的汞含量为 1.63 微克/升。鱼贝类摄入量最高四分位数（∼3 次/周）的 60 岁及以上参与者的认知评估得分显著高于最低四分位数（很少或未摄入鱼贝类）的参与者。与最低四分位数的人相比，鱼贝类摄入量最高四分位数的成年人患 SCD 的风险降低了 30%（几率比 0.7，95%CI 0.57-0.87），患 AD 的风险降低了 44%（危险比 0.56，95%CI 0.35-0.9）。结论鱼类-贝类食用量的增加与认知评估得分的提高以及SCD和AD死亡风险的降低有关。

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来源期刊

The Journal of Prevention of Alzheimer's Disease Medicine-Psychiatry and Mental Health

CiteScore

9.20

自引率

0.00%

发文量

期刊介绍： The JPAD Journal of Prevention of Alzheimer’Disease will publish reviews, original research articles and short reports to improve our knowledge in the field of Alzheimer prevention including: neurosciences, biomarkers, imaging, epidemiology, public health, physical cognitive exercise, nutrition, risk and protective factors, drug development, trials design, and heath economic outcomes.JPAD will publish also the meeting abstracts from Clinical Trial on Alzheimer Disease (CTAD) and will be distributed both in paper and online version worldwide.We hope that JPAD with your contribution will play a role in the development of Alzheimer prevention.