Intra-Articular Injection of Interleukin-8 Neutralizing Monoclonal Antibody Effectively Attenuates Osteoarthritis Progression in Rabbits.

IF 2.7 4区医学 Q1 ORTHOPEDICS CARTILAGE Pub Date : 2024-03-25 DOI:10.1177/19476035241240361

Junjun Yang, Xin Wang, Yingbo Zhang, Rui He, Zhenlan Fu, Rong Wang, Yanming Ma, Dejie Fu, Shuo Meng, Wang Cai, Yizhao Zhou, Cheng Chen, Guangxing Chen, Xiaoyuan Gong

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Abstract

Objective: Cytokines are implicated in the pathogenesis of osteoarthritis (OA), and this study aims to assess the therapeutic potential of an IL-8 neutralizing monoclonal antibody (mAb) for OA intervention.

Design: The study employed a rabbit model of OA induced by anterior cruciate ligament transection (ACLT) surgery to investigate the effects of an interleukin (IL)-8 neutralizing mAb, with hyaluronic acid (HA) used as a positive control. Primary outcomes assessed in the rabbits included cartilage repair, synovitis, joint effusion, changes in footprints, and lower limb loading conditions.

Results: Compared to HA, intra-articular injection of the IL-8 neutralizing mAb demonstrated a more pronounced attenuation of OA progression and enhancement of cartilage repair. We observed a reduction in synovitis and joint effusion, indications of bone marrow edema, as well as improvements in lower limb function. In knees treated with the neutralizing IL-8 mAb, there was a significant decrease in IL-8 levels within the synovial tissues.

Conclusions: The IL-8 neutralizing mAb exhibits promising therapeutic potential in the management of OA by attenuating inflammation and facilitating cartilage repair. However, further investigations are warranted to comprehensively elucidate the underlying mechanisms, optimize treatment protocols, and ensure the long-term safety and efficacy of this innovative therapeutic approach.

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关节内注射白细胞介素-8 中和单克隆抗体可有效减缓家兔骨关节炎的发展。

目的：细胞因子与骨关节炎（OA）的发病机制有关：细胞因子与骨关节炎（OA）的发病机制有关，本研究旨在评估IL-8中和单克隆抗体（mAb）干预OA的治疗潜力：本研究采用前十字韧带横断（ACLT）手术诱发的兔 OA 模型，研究白细胞介素（IL）-8 中和 mAb 的效果，并以透明质酸（HA）作为阳性对照。兔子的主要评估结果包括软骨修复、滑膜炎、关节积液、足印变化和下肢负荷条件：结果：与 HA 相比，关节内注射 IL-8 中和 mAb 能更明显地减缓 OA 的发展并增强软骨修复。我们还观察到滑膜炎和关节积液的减少、骨髓水肿的迹象以及下肢功能的改善。在使用中和IL-8 mAb治疗的膝关节中，滑膜组织内的IL-8水平显著下降：IL-8中和mAb可减轻炎症反应，促进软骨修复，在治疗OA方面具有广阔的前景。然而，要全面阐明其潜在机制、优化治疗方案并确保这种创新治疗方法的长期安全性和有效性，还需要进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

CARTILAGE ORTHOPEDICS-

CiteScore

6.90

自引率

7.10%

发文量

期刊介绍： CARTILAGE publishes articles related to the musculoskeletal system with particular attention to cartilage repair, development, function, degeneration, transplantation, and rehabilitation. The journal is a forum for the exchange of ideas for the many types of researchers and clinicians involved in cartilage biology and repair. A primary objective of CARTILAGE is to foster the cross-fertilization of the findings between clinical and basic sciences throughout the various disciplines involved in cartilage repair. The journal publishes full length original manuscripts on all types of cartilage including articular, nasal, auricular, tracheal/bronchial, and intervertebral disc fibrocartilage. Manuscripts on clinical and laboratory research are welcome. Review articles, editorials, and letters are also encouraged. The ICRS envisages CARTILAGE as a forum for the exchange of knowledge among clinicians, scientists, patients, and researchers. The International Cartilage Repair Society (ICRS) is dedicated to promotion, encouragement, and distribution of fundamental and applied research of cartilage in order to permit a better knowledge of function and dysfunction of articular cartilage and its repair.