Telitacicept Treatment Refractory Lupus Nephritis: A Case Report.

IF 0.7 Q4 UROLOGY & NEPHROLOGY Case Reports in Nephrology and Dialysis Pub Date : 2024-03-22 eCollection Date: 2024-01-01 DOI:10.1159/000538033

Sijia Li, Shuting Deng, Sichun Wen, Siqi Peng, Nan Jiang, Bohou Li, Boxi Chen, Ye Yuan, Qiong Wu, Yiming Tao, Jianchao Ma, Ting Lin, Feng Wen, Zhuo Li, Hao Dai, Renwei Huang, Zhonglin Feng, Zhilian Li, Shuangxin Liu, Lixia Xu

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Abstract

Introduction: Refractory lupus nephritis (LN) causes kidney disease progression and increases the risk of loss of renal function. Due to the high specificity and few side effects of biological agents, they are recommended for the treatment of systemic lupus erythematosus. There are few data on telitacicept for the treatment of refractory LN.

Case presentation: Here, we report the efficacy and safety of telitacicept in the treatment of refractory LN in a 25-year-old female patient. This patient with refractory lupus developed Pneumocystis jirovecii pneumonia while using multitargeted therapy, and the patient's urine protein was rapidly relieved after telitacicept combination with low-dose mycophenolate mofetil (MMF).

Conclusion: This result suggests that telitacicept has a positive effect on refractory LN with no significant side effects. Further reports and a registry are necessary to confirm that telitacicept with low-dose MMF should be preferred in refractory LN.

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Telitacicept 治疗难治性狼疮性肾炎：病例报告。

简介难治性狼疮肾炎（LN）会导致肾病恶化，增加肾功能丧失的风险。由于生物制剂特异性强、副作用小，因此被推荐用于治疗系统性红斑狼疮。关于替立替塞治疗难治性LN的数据很少：在此，我们报告了替利他赛治疗一名25岁女性患者难治性LN的有效性和安全性。这名难治性狼疮患者在接受多靶点治疗期间出现了肺孢子菌肺炎，在替利他赛普联合小剂量霉酚酸酯（MMF）治疗后，患者的尿蛋白症状迅速缓解：结论：这一结果表明，替立替塞对难治性 LN 有积极疗效，且无明显副作用。有必要进行进一步的报告和登记，以确认在治疗难治性LN时应首选替立替塞普联合小剂量MMF。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Case Reports in Nephrology and Dialysis UROLOGY & NEPHROLOGY-

CiteScore

1.20

自引率

0.00%

发文量

审稿时长

10 weeks

期刊介绍： This peer-reviewed online-only journal publishes original case reports covering the entire spectrum of nephrology and dialysis, including genetic susceptibility, clinical presentation, diagnosis, treatment or prevention, toxicities of therapy, critical care, supportive care, quality-of-life and survival issues. The journal will also accept case reports dealing with the use of novel technologies, both in the arena of diagnosis and treatment. Supplementary material is welcomed.