The Frailty Reduction via Implementation of Exercise, Nutrition, and Deprescribing (FRIEND) Trial: Study Protocol and Recruitment Results.

IF 2.3 Q3 BIOCHEMICAL RESEARCH METHODS Methods and Protocols Pub Date : 2024-03-22 DOI:10.3390/mps7020026
Michael Inskip, Carolina Almendrales Rangel, Chidiamara Maria Njoku, Fiona Barnett, Isabel Shih, Leonie O'Neill, Maria A Fiatarone Singh, Trinidad Valenzuela
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Abstract

Introduction: Virtually all adults in aged care facilities are frail, a condition which contributes to falls, cognitive decline, hospitalisation, and mortality. Polypharmacy, malnutrition, sedentariness, and sarcopenia are risk factors amenable to intervention. The Asia-Pacific Frailty Management Guidelines recommend anabolic exercise and the optimisation of medications and nutrition. However, no study has evaluated this best practice intervention triad in aged care.

Methods: The Frailty Reduction via the Implementation of Exercise, Nutrition, and Deprescribing (FRIEND) Trial (ANZCTR No.ACTRN12622000926730p) is a staged 6-month translational trial evaluating resident outcomes, staff/caregiver knowledge, and institutional implementation in a Townsville aged care facility. Residents received high-intensity resistance exercise and balance training and medication and nutrition optimisation co-implemented by investigators (exercise physiologist, geriatrician, pharmacist, and nutritionist) and facility staff. Staff and caregivers completed comprehensive education modules and training. We report the trial protocol and recruitment results.

Results: 29 residents (21 female, age: 88.6 ± 6.3 years) were recruited. At baseline, the residents were frail (frailty scale nursing home (FRAIL-NH); 6.3 ± 2.4/14), cognitively impaired (Montreal Cognitive Assessment; 13.8 ± 6.8/30), functionally impaired (Short Physical Performance Battery; 4.9 ± 3.1/12, 6 min walk distance; 222.2 ± 104.4 m), and were prescribed numerous medications (15.5 ± 5.9). Two residents died and one withdrew before the intervention's commencement. Thirty family members and 19 staff (carers, allied health assistants, nurse managers, registered nurses, lifestyle-leisure officers, kitchen/hospitality staff, and senior leadership) were recruited to receive frailty education modules.

Conclusions: The FRIEND trial is currently being implemented with results expected in mid-2024. This is the first trial to evaluate the implementation of the best practice frailty guidelines including anabolic exercise and medication/nutritional optimisation in residential aged care.

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通过实施运动、营养和处方减少虚弱(FRIEND)试验:研究方案和招募结果。
简介几乎所有入住老年护理机构的成年人都很虚弱,这种情况会导致跌倒、认知能力下降、住院和死亡。多药治疗、营养不良、久坐不动和肌肉疏松症是可以干预的风险因素。亚太地区虚弱管理指南》建议进行同化运动,并优化药物和营养。然而,目前还没有研究对老年护理中的这三重最佳干预措施进行评估:通过实施运动、营养和处方减少虚弱(FRIEND)试验(ANZCTR No.ACTRN12622000926730p)是一项为期 6 个月的阶段性转化试验,目的是评估汤斯维尔一家老年护理机构的居民结果、员工/护理人员知识以及机构实施情况。研究人员(运动生理学家、老年病学家、药剂师和营养学家)和养老机构员工共同为住院患者提供高强度阻力运动和平衡训练以及药物和营养优化服务。工作人员和护理人员完成了全面的教育模块和培训。我们报告了试验方案和招募结果。结果:共招募了 29 名住院患者(21 名女性,年龄:88.6 ± 6.3 岁)。基线时,住院者身体虚弱(虚弱程度量表疗养院(FRAIL-NH);6.3 ± 2.4/14),认知能力受损(蒙特利尔认知评估;13.8 ± 6.8/30),功能受损(短期体能测试;4.9 ± 3.1/12,6 分钟步行距离;222.2 ± 104.4 米),并服用多种药物(15.5 ± 5.9)。干预开始前,两名住院患者死亡,一名住院患者退出。招募了 30 名家庭成员和 19 名员工(护理人员、专职医疗助理、护士经理、注册护士、生活休闲官员、厨房/招待人员和高层领导)接受虚弱教育模块:FRIEND试验目前正在实施中,预计将于2024年中期得出结果。这是首个评估虚弱最佳实践指南(包括同化运动和药物/营养优化)在养老院中实施情况的试验。
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来源期刊
Methods and Protocols
Methods and Protocols Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (miscellaneous)
CiteScore
3.60
自引率
0.00%
发文量
85
审稿时长
8 weeks
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