N6-methylation in the development, diagnosis, and treatment of gastric cancer.

IF 4.7 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Journal of Translational Internal Medicine Pub Date : 2024-03-21 eCollection Date: 2024-02-01 DOI:10.2478/jtim-2023-0103
Jiaxin Wang, Guiping Zhao, Yan Zhao, Zheng Zhao, Shuyue Yang, Anni Zhou, Peng Li, Shutian Zhang
{"title":"N<sup>6</sup>-methylation in the development, diagnosis, and treatment of gastric cancer.","authors":"Jiaxin Wang, Guiping Zhao, Yan Zhao, Zheng Zhao, Shuyue Yang, Anni Zhou, Peng Li, Shutian Zhang","doi":"10.2478/jtim-2023-0103","DOIUrl":null,"url":null,"abstract":"<p><p>Gastric cancer (GC) ranks third among cancers in terms of mortality rate worldwide. A clear understanding of the mechanisms underlying the genesis and progression of GC will contribute to clinical decision making. N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) is the most abundant among diverse mRNA modification types and regulates multiple facets of RNA metabolism. In recent years, emerging studies have shown that m<sup>6</sup>A modifications are involved in gastric carcinoma tumorigenesis and progression and can potentially be valuable new prospects for diagnosis and prognosis. This article reviews the recent progress regarding m<sup>6</sup>A in GC.</p>","PeriodicalId":51339,"journal":{"name":"Journal of Translational Internal Medicine","volume":"12 1","pages":"5-21"},"PeriodicalIF":4.7000,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10956730/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Translational Internal Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2478/jtim-2023-0103","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/2/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0

Abstract

Gastric cancer (GC) ranks third among cancers in terms of mortality rate worldwide. A clear understanding of the mechanisms underlying the genesis and progression of GC will contribute to clinical decision making. N6-methyladenosine (m6A) is the most abundant among diverse mRNA modification types and regulates multiple facets of RNA metabolism. In recent years, emerging studies have shown that m6A modifications are involved in gastric carcinoma tumorigenesis and progression and can potentially be valuable new prospects for diagnosis and prognosis. This article reviews the recent progress regarding m6A in GC.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
胃癌发展、诊断和治疗中的 N6-甲基化。
胃癌(GC)的死亡率在全球癌症中排名第三。清楚地了解胃癌的发生和发展机制将有助于临床决策。在各种 mRNA 修饰类型中,N6-甲基腺苷(m6A)的含量最高,它调控着 RNA 代谢的多个方面。近年来,新的研究表明,m6A修饰参与了胃癌的发生和发展,并有可能成为诊断和预后的有价值的新前景。本文回顾了有关胃癌中 m6A 的最新研究进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Journal of Translational Internal Medicine
Journal of Translational Internal Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
5.50
自引率
8.20%
发文量
41
期刊最新文献
Artificial intelligence for disease X: Progress and challenges. Association of life's essential 8 with prevalence and all-cause mortality of chronic kidney disease among US adults: Results from the National Health and Nutrition Examination Survey (2015-2018). Development and validation of web-based risk score predicting prognostic nomograms for elderly patients with primary colorectal lymphoma: A population-based study. Effectiveness and safety of Qixuekang Oral Liquid on vascular health. Gene therapy in polycystic kidney disease: A promising future.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1