Bacterial diversity and chemical ecology of natural product-producing bacteria from Great Salt Lake sediment.

IF 5.1 Q1 ECOLOGY ISME communications Pub Date : 2024-03-04 eCollection Date: 2024-01-01 DOI:10.1093/ismeco/ycae029
Elijah R Bring Horvath, William J Brazelton, Min Cheol Kim, Reiko Cullum, Matthew A Mulvey, William Fenical, Jaclyn M Winter
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Abstract

Great Salt Lake (GSL), located northwest of Salt Lake City, UT, is the largest terminal lake in the USA. While the average salinity of seawater is ~3.3%, the salinity in GSL ranges between 5% and 28%. In addition to being a hypersaline environment, GSL also contains toxic concentrations of heavy metals, such as arsenic, mercury, and lead. The extreme environment of GSL makes it an intriguing subject of study, both for its unique microbiome and its potential to harbor novel natural product-producing bacteria, which could be used as resources for the discovery of biologically active compounds. Though work has been done to survey and catalog bacteria found in GSL, the Lake's microbiome is largely unexplored, and little to no work has been done to characterize the natural product potential of GSL microbes. Here, we investigate the bacterial diversity of two important regions within GSL, describe the first genomic characterization of Actinomycetota isolated from GSL sediment, including the identification of two new Actinomycetota species, and provide the first survey of the natural product potential of GSL bacteria.

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大盐湖沉积物中产生天然产物的细菌多样性和化学生态学。
大盐湖(GSL)位于犹他州盐湖城西北部,是美国最大的终端湖泊。海水的平均盐度约为 3.3%,而大盐湖的盐度则在 5% 到 28% 之间。除了高盐环境外,GSL 还含有砷、汞和铅等有毒重金属。GSL 的极端环境使其成为一个引人入胜的研究课题,因为它既有独特的微生物群落,又有潜藏新型天然产物生产细菌的潜力,这些细菌可用作发现生物活性化合物的资源。虽然已经开展了调查工作,并对在 GSL 中发现的细菌进行了编目,但该湖泊的微生物群在很大程度上尚未被探索,而且几乎没有开展任何工作来描述 GSL 微生物的天然产物潜力。在这里,我们调查了 GSL 两个重要区域的细菌多样性,描述了从 GSL 沉积物中分离出来的放线菌的首次基因组特征,包括确定了两个新的放线菌物种,并首次调查了 GSL 细菌的天然产物潜力。
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