Serum Vitamin D Concentrations in Baboons (Papio spp.) during Pregnancy and Obesity.

Comparative medicine Pub Date : 2016-04-01
Natalia E Schlabritz-Loutsevitch, Anthony G Comuzzie, Michael M Mahaney, Gene B Hubbard, Edward J Dick, Mehmet Kocak, Sonali Gupta, Maira Carrillo, Mauro Schenone, Arnold Postlethwaite, Andrzej Slominski
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Abstract

Obesity is associated with vitamin D deficiency, which can lead to serious problems during pregnancy. However, the mechanisms of the deficiency and guidelines for vitamin D supplementation during pregnancy are not established yet, and variations in environmental exposures combined with the difficulties of performing research in pregnant women are obstacles in the evaluation of vitamin D metabolism. Baboons (Papio spp.) are an excellent, well-established model for reproductive research and represent a unique opportunity to study vitamin D metabolism in a controlled environment. This study used secondary data and specimen analysis as well as a novel experimental design to evaluate pregnant and nonpregnant baboons that were or were not exposed to sunlight while they were obese and after weight reduction. Daily D3 intake was 71% higher in nonpregnant obese baboons than in their nonobese counterparts, but serum vitamin D concentrations did not differ between these populations. In addition, serum 25-hydroxyvitamin D concentrations correlated negatively with the obesity index. This report is the first to show the effect of obesity and pregnancy on vitamin D concentrations in a NHP population. These data underline the importance of adequate vitamin D supplementation in obese animals.

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狒狒(Papio spp.)妊娠和肥胖期间的血清维生素 D 浓度。
肥胖与维生素 D 缺乏有关,而维生素 D 缺乏会导致孕期出现严重问题。然而,维生素 D 缺乏的机制和孕期补充维生素 D 的指导原则尚未确立,环境暴露的变化以及在孕妇中开展研究的困难是评估维生素 D 代谢的障碍。狒狒(Papio spp.)是一种优秀的、成熟的生殖研究模型,也是在受控环境中研究维生素 D 代谢的独特机会。本研究利用二手数据和标本分析以及新颖的实验设计,对怀孕和未怀孕的狒狒在肥胖时和减轻体重后是否接触阳光进行了评估。非孕期肥胖狒狒的每日维生素D3摄入量比非孕期肥胖狒狒高出71%,但血清维生素D浓度在这些狒狒之间没有差异。此外,血清中 25- 羟维生素 D 的浓度与肥胖指数呈负相关。该报告首次显示了肥胖和妊娠对非家养动物维生素 D 浓度的影响。这些数据强调了肥胖动物补充足够维生素D的重要性。
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