PANDAS: Twenty-Five Years Later

IF 0.4 Q4 PEDIATRICS Adolescent Psychiatry Pub Date : 2024-03-20 DOI:10.2174/0122106766298492240320044542
Federico Cardelle-Pérez, María Ángeles Díaz-Caneja Greciano
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Abstract

It has been 25 years since the definition of the concept of Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS). The abrupt onset of neuropsychiatric symptoms requires a comprehensive differential diagnosis involving complementary tests and optimal treatment selection. This paper describes aspects related to the diagnosis and clinical management of PANDAS. A clinical perspective is developed starting from an example that meets the Swedo's criteria. A comprehensive approach, including interdisciplinary management and urgent evaluation of potential organic causes, is crucial for effective treatment. Treatment decisions should consider severity, symptoms, and available evidence. Collaboration with neuropediatric or neurological services is needed. ASLO/anti-DNase B and 25-OH-Vitamin D tests are valuable for atypical OCD/Tic presentations, always maintaining a broader organic screening.
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PANDAS:二十五年后
自链球菌感染相关小儿自身免疫性神经精神障碍(PANDAS)这一概念确定以来,已有25年的历史。神经精神症状的突然出现需要进行全面的鉴别诊断,包括辅助检查和最佳治疗选择。本文从符合瑞典标准的病例出发,阐述了临床观点。综合方法,包括跨学科管理和对潜在器质性病因的紧急评估,对于有效治疗至关重要。治疗决定应考虑严重程度、症状和现有证据。ASLO/抗-DNase B和25-OH-维生素D检测对非典型OCD/Tic表现很有价值,但应始终坚持进行更广泛的器质性筛查。
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来源期刊
Adolescent Psychiatry
Adolescent Psychiatry PEDIATRICS-
CiteScore
0.80
自引率
0.00%
发文量
20
期刊介绍: Adolescent Psychiatry a peer-reviewed journal, aims to provide mental health professionals who work with adolescents with current information relevant to the diagnosis and treatment of psychiatric disorders in adolescents. Adolescent Psychiatry reports of original research, critical reviews of topics relevant to practitioners, clinical observations with analysis and discussion, analysis of philosophical, ethical or social aspects of the fields of psychiatry and mental health, case reports with discussions, letters, and position papers. Topics include adolescent development and developmental psychopathology, psychotherapy and other psychosocial treatment approaches, psychopharmacology, and service settings and programs. The primary focus of the work should be on adolescents, transition-aged youth, The primary focus of the work should be on adolescents, transition-aged youth, or emerging adults, that is, persons 12-24 years of age . Articles on families of adolescents, or adults who have been followed since adolescence will also be considered.
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