Chelsea A. Crossley, Tamunotonye Omoluabi, Sarah E. Torraville, Sarah Duraid, Aida Maziar, Zia Hasan, Vishaal Rajani, K. Ando, Johannes W Hell, Qi Yuan
{"title":"Hippocampal hyperphosphorylated tau-induced deficiency is rescued by L-type calcium channel blockade","authors":"Chelsea A. Crossley, Tamunotonye Omoluabi, Sarah E. Torraville, Sarah Duraid, Aida Maziar, Zia Hasan, Vishaal Rajani, K. Ando, Johannes W Hell, Qi Yuan","doi":"10.1093/braincomms/fcae096","DOIUrl":null,"url":null,"abstract":"\n Aging and Alzheimer’s disease are associated with chronic elevations in neuronal calcium influx via L-type calcium channels. The hippocampus, a primary memory encoding structure in the brain, is more vulnerable to calcium dysregulation in Alzheimer’s disease. Recent research has suggested a link between L-type calcium channels and tau hyperphosphorylation. However, the precise mechanism of L-type calcium channel-mediated tau toxicity is not understood.","PeriodicalId":9318,"journal":{"name":"Brain Communications","volume":"28 28","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain Communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/braincomms/fcae096","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Aging and Alzheimer’s disease are associated with chronic elevations in neuronal calcium influx via L-type calcium channels. The hippocampus, a primary memory encoding structure in the brain, is more vulnerable to calcium dysregulation in Alzheimer’s disease. Recent research has suggested a link between L-type calcium channels and tau hyperphosphorylation. However, the precise mechanism of L-type calcium channel-mediated tau toxicity is not understood.
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