Majid Hamid Rasool, Ali J. Al-Nuaimi, Juman Khaleel Al-Sabbagh
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引用次数: 0
Abstract
Bisphenol A (BPA) is an endocrine disruptor and an environmental pollutant; it can produce free radicals, which cause damage in various tissues. Curcumin has been demonstrated to help with a variety of male reproductive diseases, as well as to scavenge free radicals and function as an antioxidant. The aim is to estimate the protective role of Curcumin against the toxic effect of BPA in male rats by determining the levels of antioxidants and sexual hormones, before and after treatment with this herb. The effect of curcumin as a protective role against BPA on the oxidative stress parameters showed that Curcumin could decrease MDA concentration and at the same time increase the concentration of both catalase and SOD. Also, the results revealed that Curcumin could increase the concentration of LH, FSH, and testosterone as compared to the BPA-treated group.
双酚 A（BPA）是一种内分泌干扰物和环境污染物；它能产生自由基，对各种组织造成损害。姜黄素被证明有助于治疗多种男性生殖疾病，还能清除自由基，发挥抗氧化剂的作用。本研究的目的是通过测定使用姜黄素治疗前后雄性大鼠体内的抗氧化剂和性激素水平，评估姜黄素对双酚 A 毒性作用的保护作用。姜黄素对双酚 A 的氧化应激参数的保护作用表明，姜黄素可以降低 MDA 浓度，同时提高过氧化氢酶和 SOD 的浓度。此外，与双酚 A 组相比，姜黄素还能提高 LH、FSH 和睾酮的浓度。
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