MicroRNAs as Potential Biomarkers for the Diagnosis, Treatment, and Prognosis of Sexually Transmitted Diseases: Recent Advances and Future Directions

IF 3.7 4区医学 Q1 DERMATOLOGY Dermatologic Therapy Pub Date : 2024-03-18 DOI:10.1155/2024/7835561

Shiyang Li, Ming Wang, Meihua He, Yi Xu, Changxia Li, Yue Huang, Xiaohua Tao

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Abstract

Sexually transmitted diseases (STDs), including condyloma acuminatum (CA), syphilis, gonorrhea, genital Chlamydia trachomatis (CT), and acquired immune deficiency syndrome (AIDS)/human immunodeficiency virus (HIV) infection, are a group of diseases primarily transmitted through sexual contact, similar behaviors, and indirect contact. These diseases exert a profound impact on both the physical and mental health of patients and impose a substantial socioeconomic burden. Nonetheless, there is a lack of satisfactory treatment options and preventive strategies currently. Research has revealed aberrant expression patterns of microRNAs (miRNAs) in the tissues and blood of individuals with STDs, which are involved in the regulation of essential cellular processes, including proliferation, differentiation, and apoptosis. Consequently, miRNAs hold promise as crucial biomarkers for early diagnosis, disease assessment, prognosis, and potential therapeutic targets for STDs. This systematic review presents pertinent research on miRNAs in the context of STDs to establish a theoretical foundation for clinical diagnosis and treatment strategies.

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作为性传播疾病诊断、治疗和预后潜在生物标记物的微RNA：最新进展与未来方向

性传播疾病（STD），包括尖锐湿疣（CA）、梅毒、淋病、生殖器沙眼衣原体（CT）和获得性免疫缺陷综合征（AIDS）/人类免疫缺陷病毒（HIV）感染，是一组主要通过性接触、类似行为和间接接触传播的疾病。这些疾病对患者的身心健康产生了深远的影响，并造成了巨大的社会经济负担。然而，目前还缺乏令人满意的治疗方案和预防策略。研究发现，在性传播疾病患者的组织和血液中，微小核糖核酸（miRNA）的表达模式存在异常，而这些微小核糖核酸参与了细胞增殖、分化和凋亡等重要过程的调控。因此，miRNAs有望成为性传播疾病早期诊断、疾病评估、预后判断的重要生物标志物和潜在治疗靶点。这篇系统性综述介绍了性传播疾病中 miRNAs 的相关研究，为临床诊断和治疗策略奠定了理论基础。

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来源期刊

Dermatologic Therapy 医学-皮肤病学

CiteScore

7.00

自引率

8.30%

发文量

711

审稿时长

3 months

期刊介绍： Dermatologic Therapy has been created to fill an important void in the dermatologic literature: the lack of a readily available source of up-to-date information on the treatment of specific cutaneous diseases and the practical application of specific treatment modalities. Each issue of the journal consists of a series of scholarly review articles written by leaders in dermatology in which they describe, in very specific terms, how they treat particular cutaneous diseases and how they use specific therapeutic agents. The information contained in each issue is so practical and detailed that the reader should be able to directly apply various treatment approaches to daily clinical situations. Because of the specific and practical nature of this publication, Dermatologic Therapy not only serves as a readily available resource for the day-to-day treatment of patients, but also as an evolving therapeutic textbook for the treatment of dermatologic diseases.