Prognostic value of neutrophil-to-lymphocyte ratio (NLR) and platelet-neutrophil (PN) index in locally advanced rectal cancer patients: a retrospective cohort study

Annals of Medicine & Surgery Pub Date : 2024-03-18 DOI:10.1097/ms9.0000000000001297

Marina Morais, Telma Fonseca, Raquel Machado-Neves, Mrinalini Honavar, Ana Rita Coelho, Joanne Lopes, Emanuel Guerreiro, Silvestre Carneiro

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Abstract

In locally advanced rectal cancers (LARC), TNM staging is far from optimal. We aimed to investigate the value of previously described circulating biomarkers as predictors of prognosis. Retrospective analysis of 245 LARC patients diagnosed between January 2010 and December 2022, who underwent neoadjuvant chemoradiotherapy and surgery at two centers. A Cox regression and Kaplan-Meier analysis were performed. Posttreatment platelet-to-lymphocyte ratio (PLR) predicted pCR. Neutrophil-to-lymphocyte ratio (NLR) in two timepoints of the treatment significantly predicted overall survival, whereas platelet-neutrophil (PN) index significantly predicted disease-free survival. In pathological stage II, PN index predicted patients of higher risk of disease-free survival. Blood parameters might allow the definition of subgroups of risk, beyond TNM, for the application of different therapeutic strategies.

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局部晚期直肠癌患者中性粒细胞与淋巴细胞比值（NLR）和血小板-中性粒细胞（PN）指数的预后价值：一项回顾性队列研究

在局部晚期直肠癌（LARC）中，TNM 分期远非最佳。我们旨在研究之前描述的循环生物标志物作为预后预测因子的价值。我们对2010年1月至2022年12月期间确诊的245例LARC患者进行了回顾性分析，这些患者在两个中心接受了新辅助化放疗和手术。研究人员进行了Cox回归和Kaplan-Meier分析。治疗后血小板淋巴细胞比值（PLR）可预测pCR。治疗两个时间点的中性粒细胞与淋巴细胞比值（NLR）可显著预测总生存期，而血小板-中性粒细胞（PN）指数可显著预测无病生存期。在病理分期 II 中，PN 指数可预测无病生存风险较高的患者。除 TNM 外，血液参数还可用于定义风险亚组，以应用不同的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Annals of Medicine & Surgery

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