Parvesh Singh, Gobind Kumar, L. Khubone, P. Seboletswe, Neha Manhas, Talent R. Makhanya, Gaurav Bhargava
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引用次数: 0
Abstract
A green, sustainable, and efficient one-pot, synthetic strategy for the synthesis of 2,3-dihydroquinazolin-4(1 H )- ones (DHQs) was developed. The ZnCl 2 /urea used as a deep eutectic solvent (DES) not only efficiently promoted the condensation between isatoic anhydride and benzaldehyde but unexpectedly acted as a nitrogen source (like ammonia) in sit u to afford DHQs in excellent yields. This approach offers remarkable advantages, involving the triple role of DES in the synthesis of DHQs, atom-economical, green organocatalysts, metal-free conditions, cost-effectiveness, and tolerance to a range of functional groups
本研究开发了一种绿色、可持续和高效的单锅合成 2,3-二氢喹唑啉-4(1 H )- 1（DHQs）的合成策略。用作深共晶溶剂（DES）的 ZnCl 2 /尿素不仅有效地促进了异酸酐和苯甲醛之间的缩合，还意外地在 sit u 中充当了氮源（如氨）的角色，从而以优异的产率获得了 DHQs。这种方法具有显著的优势，包括 DES 在 DHQs 合成中的三重作用、原子经济的绿色有机催化剂、无金属条件、成本效益以及对一系列官能团的耐受性。
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