Design, synthesis of novel Schiff bases as potential insecticidal agents against Spodoptera frugiperda (Lepidoptera: Noctuidae)

IF 1.3 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Bulletin of the Chemical Society of Ethiopia Pub Date : 2024-03-12 DOI:10.4314/bcse.v38i3.17

Faeza Alkorbi, Mahmoud A. Abdelaziz, Wafa Mazi, Noha Omer, Rasha Jame, Mohamed A. Gad, Omran A. Omran, Ali M. Ali

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Abstract

In the present work, novel series of Schiff base 2-7 were synthesized via treatment of p-tosyloxy benzaldehyde with some indole and quinoxaline derivatives in ethanol under reflux. All product structures were verified using elemental analysis and spectroscopic investigations, including 13C NMR, 1H NMR, and IR. Our research was conducted on the insecticidal activity, and biological effects of the recently synthesized Schiff bases on S. frugiperda. The results showed that compound 5 was the most active insecticide, nearly surpassing methomyl as a reference, with LC50 values of 46.35 mg/L for second-instar larvae and 97.37 mg/L for fourth-instar larvae. This research opened up new avenues for the search for a novel class of insecticide. KEY WORDS: Schiff bases, Spodoptera frugiperda, Insecticidal activity, Biological aspects, Toxicity Bull. Chem. Soc. Ethiop. 2024, 38(3), 765-774. DOI: https://dx.doi.org/10.4314/bcse.v38i3.17

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设计和合成新型席夫碱，作为潜在的杀虫药剂防治鞘翅目蛙蛾 (鳞翅目：夜蛾科)

本研究在乙醇回流条件下，通过处理对甲苯磺酰氧基苯甲醛与一些吲哚和喹喔啉衍生物，合成了新系列的希夫碱 2-7。所有产物的结构都通过元素分析和光谱研究（包括 13C NMR、1H NMR 和 IR）得到了验证。我们研究了最近合成的希夫碱对蚜虫的杀虫活性和生物效应。结果表明，化合物 5 是活性最高的杀虫剂，几乎超过了作为参考的灭多威，其对二龄幼虫的半致死浓度为 46.35 毫克/升，对四龄幼虫的半致死浓度为 97.37 毫克/升。这项研究为寻找新型杀虫剂开辟了新途径。关键字：席夫碱，鞘翅目，杀虫活性，生物学方面，毒性 Bull.Chem.Soc.2024, 38(3), 765-774. DOI: https://dx.doi.org/10.4314/bcse.v38i3.17

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来源期刊

Bulletin of the Chemical Society of Ethiopia 化学-化学综合

CiteScore

2.20

自引率

8.30%

发文量

113

审稿时长

6-12 weeks

期刊介绍： The Bulletin of the Chemical Society of Ethiopia (BCSE) is a triannual publication of the Chemical Society of Ethiopia. The BCSE is an open access and peer reviewed journal. The BCSE invites contributions in any field of basic and applied chemistry.