New approaches for the synthesis of chromene and quinoline derivatives and their anti-proliferative, morphological studies

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-03-12 DOI:10.4314/bcse.v38i3.18

Rafat Milad Mohareb, Hanan Maged Labib

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Abstract

This work aimed to evaluate the anticancer potential of the novel 5,6,7,8-tetrahydro-4H-chromenes against selected six cancer cell lines together with the prostate cancer cell line PC-3. A novel series of substituted 5,6,7,8-tetrahydro-4H-chromenes were synthesized through feasible synthetic strategy. The synthetic schemes involve firstly the multi-component reactions of dimedone with the aromatic aldehydes and ethyl acetoacetate to produce the 5,6,7,8-tetrahydro-4H-chromenes derivatives. On the other hand, carrying the same reactions using NH4OAc produced the hexahydroquinoline compounds. Anti-proliferative evaluations and inhibitions for all synthesized compounds toward selected cancer cell lines were carried out and the results revealed that many of them exhibited high inhibitions. Morphology of A549 cell line by the effect of compounds 14f and 16c was performed. KEY WORDS: Anti-proliferative activity, Chromene derivatives, Morphology, Multi-component reactions Bull. Chem. Soc. Ethiop. 2024, 38(3), 775-798. DOI: https://dx.doi.org/10.4314/bcse.v38i3.18

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合成铬烯和喹啉衍生物的新方法及其抗增殖和形态学研究

这项研究旨在评估新型 5,6,7,8-四氢-4H-色烯对所选的六种癌细胞株和前列腺癌细胞株 PC-3 的抗癌潜力。通过可行的合成策略，合成了一系列新型取代的 5,6,7,8-四氢-4H-苯并吡喃。合成方案首先涉及二甲酮与芳香醛和乙酰乙酸乙酯的多组分反应，生成 5,6,7,8-四氢-4H-苯并吡喃衍生物。另一方面，使用 NH4OAc 进行相同的反应可生成六氢喹啉化合物。研究人员对所有合成的化合物进行了抗增殖评估，并对选定的癌细胞株进行了抑制，结果表明其中许多化合物都具有很强的抑制作用。在化合物 14f 和 16c 的作用下，对 A549 细胞系进行了形态学研究。关键字：抗增殖活性，色烯衍生物，形态学，多组分反应 Bull.Chem.Soc.2024, 38(3), 775-798. DOI: https://dx.doi.org/10.4314/bcse.v38i3.18

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.