Boosted antibacterial efficacy: Di and triorganotin complexes via 2-[(2,3-dimethylphenyl)amino]benzoic acid

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-03-12 DOI:10.4314/bcse.v38i3.8

Rana S. Al-Shemary, Hadeer Jasem, Angham G. Hadi, Sadiq J. Baqir

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Abstract

Using appropriate organotin chloride salts and a ligand called 2-[(2,3-dimethylphenyl) amino] benzoic acid (DMPAB), a condensation procedure produced novel complexes such as triphenyltin, dimethyl, diphenyl, and dibutyl-tin. For difficult identification, a variety of analytical methods were used, including elemental analysis, carbon and proton magnetic resonance, and infrared spectra. The agar ditch method was used to assess the antibacterial effectiveness against Staphylococcus aureus and Escherichia coli. When compared to the molecule generated from the ligand, the complexes showed more inhibitory action. Among the complexes tested, the dimethyltin carboxylate complex showed the strongest antibacterial action against Staphylococcus aureus and Escherichia coli. KEY WORDS: Complexes, Antibacterial properties, Condensation process, Agar Ditch, Staphylococcus aureus and Escherichia coli Bull. Chem. Soc. Ethiop. 2024, 38(3), 647-655. DOI: https://dx.doi.org/10.4314/bcse.v38i3.8

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增强抗菌功效：通过 2-[(2,3-二甲基苯基)氨基]苯甲酸的二有机锡和三有机锡络合物

利用适当的有机锡氯化物盐和一种名为 2-[（2,3-二甲基苯基）氨基]苯甲酸（DMPAB）的配体，通过缩合程序产生了新型络合物，如三苯基锡、二甲基锡、二苯基锡和二丁基锡。在难以识别的情况下，采用了多种分析方法，包括元素分析、碳和质子磁共振以及红外光谱。琼脂沟法用于评估对金黄色葡萄球菌和大肠杆菌的抗菌效果。与配体生成的分子相比，复合物显示出更强的抑制作用。在测试的复合物中，羧酸二甲基锡复合物对金黄色葡萄球菌和大肠杆菌的抗菌作用最强。关键词：络合物、抗菌特性、缩合过程、琼脂沟、金黄色葡萄球菌和大肠杆菌 Bull.Chem.Soc.2024, 38(3), 647-655. DOI: https://dx.doi.org/10.4314/bcse.v38i3.8

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.