ELUCIDATING THE MECHANISMS OF NEUTROPHIL EXTRACELLULAR TRAPS IN ACUTE RESPIRATORY DISTRESS SYNDROME PATHOGENESIS

Abstract

This article critically examines the scientific literature related to the formation of neutrophil extracellular traps and their impact on the pathogenesis and clinical course of acute respiratory distress syndrome (ARDS). The available evidence indicates that the formation and accumulation of neutrophil extracellular traps in the lung tissue are implicated in the development and progression of ARDS. Moreover, recent studies have shed light on the potential mechanisms by which neutrophil extracellular traps contribute to impaired ventilationperfusion relationships in ARDS. The findings presented in this review suggest that further research into the phenomenon of neutrophil extracellular traps may lead to new insights into the pathophysiology of ARDS and inform the development of novel therapeutic strategies. Specifically, targeting neutrophil extracellular traps may offer a promising approach to attenuate the severity of ARDS and improve clinical outcomes. However, the complexity of the underlying mechanisms and the heterogeneity of ARDS patients necessitate further investigation to identify optimal therapeutic targets and treatment strategies.