K+ Ions Crosslinked Kappa-Carrageenan/Methylene Blue Composite Film. Part-1: Synthesis, Characterization and Application as Controlled Release Device for Photodynamic Therapy Application

Abstract

K+ ions crosslinked (KC/MB) Methylene blue photosensitizer loaded composite film is prepared for photodynamic therapy (PDT) application as Photosensitizer released by composite film can conveniently be controlled by using different quantities of K+ ions and this application is based on dynamic interaction between light with suitable wavelength, photosensitizer and molecular oxygen, promoting the death of the target tissue or bacterial cells. In this work, the Methylene Blue (MB) loaded Carrageenan polymeric film was prepared by the method of direct addition of MB into pre-polymerization solution of Carrageenan (KC). This composite film and plain KC film were characterized by FTIR, XRD and SEM analysis. The characteristic peaks of MB photosensitizer were obtained in FTIR spectrum of composite film. The composite film KC/MB shows prominence of amorphous nature may be due to MB is present in very small quantity. The SEM analysis reveals that the composite film (KC/MB) having much more smooth surface texture throughout the film. Finally, the result of effect of variation in degree of crosslinking on amount of MB release is, as the amount of K+ ions used to crosslink the film increases, MB release decreases.