Development of a Smartphone-linked Optical Biosensing System for Point-of-care Testing Applications

IF 17.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-03-08 DOI:10.18494/sam4851

Miku Sarubo, Yuka Numazaki, Hiroyuki Kudo

引用次数: 0

Abstract

We report a miniaturized batteryless colorimetric biosensing system for measuring saliva components. Our system utilizes a CMOS image sensor and an LED light source embedded in smartphones as a part of the optical system. We measured the concentration of chemical substances by observing color changes of the coloring reagent DA-64, which is specific for hydrogen peroxide. The concentration calculated from the RGB scores of colorimetric images showed strong correlations ( r > 0.95) with the concentrations of the samples. This result shows the possibility of biochemical measurements using miniaturized biosensing systems to determine physiological conditions.

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为护理点检测应用开发与智能手机相连的光学生物传感系统

我们报告了一种用于测量唾液成分的微型无电池比色生物传感系统。我们的系统利用 CMOS 图像传感器和嵌入智能手机的 LED 光源作为光学系统的一部分。我们通过观察着色试剂 DA-64 的颜色变化来测量化学物质的浓度，DA-64 对过氧化氢具有特异性。根据比色图像的 RGB 分数计算出的浓度与样品浓度有很强的相关性（r > 0.95）。这一结果表明，可以利用微型生物传感系统进行生化测量，以确定生理状况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.