Seroconversion of the CoronaVac® Vaccine from One Dose in an Outbreak of COVID-19 Infection at a Long-term Care Institution

IF 1 Q4 HEALTH POLICY & SERVICES Journal of Health Management Pub Date : 2024-03-03 DOI:10.1177/09720634241229240
N. M. Hallage, Regina Maura Zetoni Crespan, A. C. M. Gaiatto, T. A. Bibo, Nicolle de Godoy Moreira e Costa, Beatriz da Costa Aguiar Alves, Thaís Gascón, J. Raimundo, J. A. Encinas, M. Perez, G. L. Veiga, F. Fonseca
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Abstract

The purpose of this study is to assess the vaccine response to the COVID-19 outbreak installed at the institution. To conduct this case report, 36 individuals were evaluated, among residents and employees of this institution. Blood samples were collected by venipuncture and the presence of antibodies to SARS-CoV-2 (total antibodies, IgG and IgM) were analysed in these samples; 25% of patients/staff ( n = 9) seroconverted with only the first dose of CoronaVac® in just 14 days after the first dose of the vaccine. These individuals did not developed symptoms of COVID-19 during the outbreak that occurred at the institution. Vaccine response to CoronaVac®, after an outbreak of COVID-19 at the studied institution, was higher than the response postulated in other previously published studies with detection of SARS-CoV-2 antibodies before the second dose of the vaccine.
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在一家长期护理机构爆发的 COVID-19 感染疫情中,CoronaVac® 疫苗接种一剂即发生血清转换
本研究旨在评估该机构对 COVID-19 爆发的疫苗反应。为进行本病例报告,对该机构的居民和员工中的 36 人进行了评估。通过静脉穿刺采集了血液样本,并对这些样本中是否存在 SARS-CoV-2 抗体(总抗体、IgG 和 IgM)进行了分析;25% 的患者/员工(9 人)在接种第一剂 CoronaVac® 后仅 14 天内就发生了血清转换。在该机构爆发疫情期间,这些人并未出现 COVID-19 症状。在研究机构爆发 COVID-19 疫情后,对 CoronaVac® 疫苗的反应高于之前发表的其他研究中推测的反应,即在接种第二剂疫苗前检测到 SARS-CoV-2 抗体。
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来源期刊
Journal of Health Management
Journal of Health Management HEALTH POLICY & SERVICES-
CiteScore
3.40
自引率
0.00%
发文量
84
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