{"title":"Chemistry of nitrogen dioxide and its biological implicatios","authors":"Sara Goldstein , Amram Samuni","doi":"10.1016/j.rbc.2024.100020","DOIUrl":null,"url":null,"abstract":"<div><p>Nitrogen dioxide (<sup>•</sup>NO<sub>2</sub>) is a radical gas that forms part of air pollution and is produced chemically, photochemically and by ionizing radiation in aqueous and non-aqueous solutions as well as by various endogenous pathways in biological systems. This review describes the: (<em>i</em>) sources of <sup>•</sup>NO<sub>2</sub>; (<em>ii</em>) kinetics and mechanism of <sup>•</sup>NO<sub>2</sub> reactions; (<em>iii</em>) <sup>•</sup>NO<sub>2</sub> as a key player in cellular oxidative and nitrosative stress leading to pathological conditions, and <em>(iv)</em> use of diverse antioxidants to reduce <sup>•</sup>NO<sub>2</sub> toxic effects.</p></div>","PeriodicalId":101065,"journal":{"name":"Redox Biochemistry and Chemistry","volume":"7 ","pages":"Article 100020"},"PeriodicalIF":0.0000,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773176624000014/pdfft?md5=1281d8224d83c88cf2e2284ffe34567c&pid=1-s2.0-S2773176624000014-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Redox Biochemistry and Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2773176624000014","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Nitrogen dioxide (•NO2) is a radical gas that forms part of air pollution and is produced chemically, photochemically and by ionizing radiation in aqueous and non-aqueous solutions as well as by various endogenous pathways in biological systems. This review describes the: (i) sources of •NO2; (ii) kinetics and mechanism of •NO2 reactions; (iii) •NO2 as a key player in cellular oxidative and nitrosative stress leading to pathological conditions, and (iv) use of diverse antioxidants to reduce •NO2 toxic effects.
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