Analysis of a Serious Adverse Reaction of Pulmonary Fibrosis Caused by Dronedarone

IF 1.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Current Therapeutic Research-clinical and Experimental Pub Date : 2024-01-01 DOI:10.1016/j.curtheres.2024.100743

Yuyan Chen PM , Zhendong Fu MM , Xue Wen MM , Mingxia Zhang PM , Qiong Min PM , Peng Wang PM , Jin Zhang MB , Jun Ren PM , Wenbin Li PD , Rong Wang PD

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Abstract

Objective

This study aims to analyze a severe adverse reaction of pulmonary fibrosis induced by dronedarone hydrochloride tablets, and to provide a reference for clinical rational medication through drug precautions.

Methods

A case of pulmonary fibrosis induced by dronedarone hydrochloride tablets, along with related literature was retrospectively analyzed.

Results

Patients over 65 years old with a history of exposure to amiodarone may increase the incidence of pulmonary toxicity induced by dronedarone, and dronedarone should not be selected as a substitute treatment drug for patients with amiodarone-induced pulmonary toxicity.

Conclusions

It is recommended that clinicians monitor the diffusion capacity of carbon monoxide and lung ventilation function of patients before and after using dronedarone for treatment. For patients with a history of amiodarone exposure, intermittent monitoring of chest X-rays and lung function is necessary. If lung function decreases, dronedarone should be immediately discontinued.

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分析决奈达隆导致肺纤维化的严重不良反应

摘要】目的分析盐酸决奈达隆片剂诱发肺纤维化的严重不良反应，通过用药注意事项为临床合理用药提供参考。方法回顾性分析1例盐酸决奈达隆片剂诱发肺纤维化的病例及相关文献。结果65岁以上有胺碘酮接触史的患者可能会增加决奈达隆诱发肺毒性的发生率，不应选择决奈达隆作为胺碘酮诱发肺毒性患者的替代治疗药物。对于有胺碘酮接触史的患者，有必要间歇性监测胸部 X 光片和肺功能。如果肺功能下降，应立即停用决奈达隆。

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来源期刊

Current Therapeutic Research-clinical and Experimental 医学-药学

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

3 months

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