The roles of long non-coding RNAs in Alzheimer's disease diagnosis, treatment, and their involvement in Alzheimer's disease immune responses

IF 5.9 3区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Non-coding RNA Research Pub Date : 2024-03-16 DOI:10.1016/j.ncrna.2024.03.008

Xiaoben Wu , Pengcheng Xia , Lei Yang , Chao Lu , Zhiming Lu

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Abstract

Alzheimer's disease (AD) is the most frequent type of dementia, presenting a substantial danger to the health and well-being of the aged population. It has arisen as a significant public health problem with considerable socioeconomic repercussions. Unfortunately, no effective treatments or diagnostic tools are available for Alzheimer's disease. Despite substantial studies on the pathophysiology of Alzheimer's, the molecular pathways underpinning its development remain poorly understood. Long non-coding RNAs (lncRNAs) vary in size from 200 nucleotides to over 100 kilobytes and have been found to play critical roles in various vital biological processes that play critical in developing Alzheimer's disease. This review intends to examine the functions of long non-coding RNAs in diagnosing and treating Alzheimer's disease and their participation in immunological responses associated with AD.

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长非编码 RNA 在阿尔茨海默病诊断和治疗中的作用及其参与阿尔茨海默病免疫反应的情况

阿尔茨海默病（AD）是最常见的痴呆类型，对老年人群的健康和福祉构成巨大威胁。它已成为一个重大的公共卫生问题，对社会经济产生了相当大的影响。遗憾的是，目前还没有针对阿尔茨海默病的有效治疗方法或诊断工具。尽管对阿尔茨海默病的病理生理学进行了大量研究，但对其发病的分子途径仍然知之甚少。长非编码 RNA（lncRNA）的大小从 200 个核苷酸到超过 100 千字节不等，已被发现在各种重要的生物过程中发挥关键作用，而这些过程在阿尔茨海默氏症的发病过程中起着至关重要的作用。本综述旨在研究长非编码 RNA 在诊断和治疗阿尔茨海默病中的功能，以及它们在与阿尔茨海默病相关的免疫反应中的参与。

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来源期刊

Non-coding RNA Research Medicine-Biochemistry (medical)

CiteScore

7.70

自引率

6.00%

发文量

审稿时长

49 days

期刊介绍： Non-coding RNA Research aims to publish high quality research and review articles on the mechanistic role of non-coding RNAs in all human diseases. This interdisciplinary journal will welcome research dealing with all aspects of non-coding RNAs-their biogenesis, regulation and role in disease progression. The focus of this journal will be to publish translational studies as well as well-designed basic studies with translational and clinical implications. The non-coding RNAs of particular interest will be microRNAs (miRNAs), small interfering RNAs (siRNAs), small nucleolar RNAs (snoRNAs), U-RNAs/small nuclear RNAs (snRNAs), exosomal/extracellular RNAs (exRNAs), Piwi-interacting RNAs (piRNAs) and long non-coding RNAs. Topics of interest will include, but not limited to: -Regulation of non-coding RNAs -Targets and regulatory functions of non-coding RNAs -Epigenetics and non-coding RNAs -Biological functions of non-coding RNAs -Non-coding RNAs as biomarkers -Non-coding RNA-based therapeutics -Prognostic value of non-coding RNAs -Pharmacological studies involving non-coding RNAs -Population based and epidemiological studies -Gene expression / proteomics / computational / pathway analysis-based studies on non-coding RNAs with functional validation -Novel strategies to manipulate non-coding RNAs expression and function -Clinical studies on evaluation of non-coding RNAs The journal will strive to disseminate cutting edge research, showcasing the ever-evolving importance of non-coding RNAs in modern day research and medicine.