Role of Nano-Bioceramic Bone Graft on the Healing Process of Unfavorable Mandibular Angle Fracture (An experimental study)

Abstract

Introduction: The most frequent fracture is a mandibular angle fracture, which is challenging to treat because there is no established universal technique. So, for diverse implant systems, different kinds of plates have been developed. Aim: This study aimed to evaluate of nano bio-ceramic bone graft with 3D bone plate on the healing of unfavorable mandibular angle fracture. Material and methods: This study included 18 male adult mongrel dogs, animals were divided into (9 of each): study group (I) where the angle fracture treated by 3 dimension bone plate with Nano bio glass bone graft. Control group (II) where the angle fracture treated by 3 dimension bone plate only. Noncritical size bone defects (3 mm diameter) were created in the mandibular angle of the dogs. Bone density was measured in the vicinity of the fracture line using the cone beam (CBCT). Results: Dogs were euthanized at 3, 6 and 12 weeks postoperatively, six dogs at a time, three dogs from each group. All of the 18 fracture line healed uneventfully. Soft tissue healing normally proceeded without any signs of infection. Post-operative assessment of the current study revealed no obvious complications; neither post-operative infection nor wound dehiscence was detected in any case. The synthetic Nano bio glass bone graft was bio compatible and non-allergic. CBCT showed that measurements of the bone density reading were increased in study group more than control group throughout showing highly significantly reading after 12 weeks. The measurements of the bone density were higher in the study group than control group throughout the whole study intervals. Conclusion: 3D Titanium plates have superior biomechanical properties and biocompatibility when used in treatment of fractures of the angle. Nano bio glass bone graft is a compatible material and doesn’t interfere with the healing process of fracture filed.