{"title":"The unusual substrate specificity of Escherichia coli cardiolipin synthase C does not require the product of the transcriptionally engaged ymdB gene","authors":"Katsuhiro Sawasato, Mikhail Bogdanov","doi":"10.1016/j.bbalip.2024.159483","DOIUrl":null,"url":null,"abstract":"<div><p>Polycistronic transcription and translation of <em>ymdB</em>-<em>clsC</em> have been thought to be required for full activity of ClsC.</p><p>The authentic initiation codon of the <em>clsC</em> gene is present within the open reading frame of the upstream located <em>ymdB</em> gene.</p><p>ClsC translated from authentic initiation codon drives cardiolipin (CL) synthesis without transcriptionally paired YmdB.</p><p>YmdB is not necessary for the substrate specificity of ClsC utilizing phosphatidylethanolamine (PE) as a co-substrate.</p></div>","PeriodicalId":8815,"journal":{"name":"Biochimica et biophysica acta. Molecular and cell biology of lipids","volume":null,"pages":null},"PeriodicalIF":3.9000,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochimica et biophysica acta. Molecular and cell biology of lipids","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1388198124000337","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Polycistronic transcription and translation of ymdB-clsC have been thought to be required for full activity of ClsC.
The authentic initiation codon of the clsC gene is present within the open reading frame of the upstream located ymdB gene.
ClsC translated from authentic initiation codon drives cardiolipin (CL) synthesis without transcriptionally paired YmdB.
YmdB is not necessary for the substrate specificity of ClsC utilizing phosphatidylethanolamine (PE) as a co-substrate.
期刊介绍：
BBA Molecular and Cell Biology of Lipids publishes papers on original research dealing with novel aspects of molecular genetics related to the lipidome, the biosynthesis of lipids, the role of lipids in cells and whole organisms, the regulation of lipid metabolism and function, and lipidomics in all organisms. Manuscripts should significantly advance the understanding of the molecular mechanisms underlying biological processes in which lipids are involved. Papers detailing novel methodology must report significant biochemical, molecular, or functional insight in the area of lipids.
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