Plasma Cell-Free Adenomatous Polyposis Coli Gene Promoter Methylation as a Prognostic Biomarker for Hepatocellular Carcinoma.

IF 2.5 3区医学 Q3 ONCOLOGY Oncology Pub Date : 2024-01-01 Epub Date: 2024-03-25 DOI:10.1159/000538455

Chih-Yang Hsiao, Chang-Yi Lu, Hung-Ju Su, Kai-Wen Huang

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Abstract

Introduction: Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide. Lack of biomarkers for follow-up after treatment is a clinical challenge. DNA methylation has been proposed to be a potential biomarker in HCC. However, there is still a lack of evidence of its clinical use. This study aimed to evaluate the value of using plasma Adenomatous Polyposis Coli promoter methylation level (APC-MET) as a potential biomarker in HCC treatment.

Method: A total of 96 patients with HCC at BCLC stage B who underwent local tumor ablation treatment were prospectively included in this study. APC-MET was examined in the plasma of each patient before and 1 month after treatment. The prediction value of APC-MET for survival outcome and disease status after treatment was analyzed and adjusted with alpha-fetoprotein and protein induced by vitamin K absence-II using Cox regression analysis.

Results: Univariate Cox regression analysis showed preoperative APC-MET >0 (HR, 2.9, 95% CI: 1.05-8.05, p = 0.041) and postoperative APC-MET >0 (HR, 3.47, 95% CI: 1.16-10.4, p = 0.026) were both predictors of death, and preoperative APC-MET >0 was a predictor of disease progression after treatment (HR, 2.04, 95% CI: 1.21-3.44, p = 0.007). In multivariate models, preoperative APC-MET >0 was a significant predictor of disease progression after adjusting with the other two traditional biomarkers (HR, 1.82, 95% CI: 1.05-3.17, p = 0.034).

Conclusions: Hypermethylation of APC promoter appears to be a potential biomarker that could predict patient survival and disease progression outcomes in patients with intermediate-stage HCC after local ablation treatment.

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血浆细胞游离腺瘤性息肉病大肠杆菌基因启动子甲基化作为肝细胞癌的预后生物标志物

简介肝细胞癌（HCC）是全球癌症死亡的主要原因。缺乏治疗后随访的生物标志物是一项临床挑战。DNA 甲基化被认为是 HCC 的潜在生物标志物。然而，目前仍缺乏其临床应用的证据。本研究旨在评估血浆腺瘤性息肉病大肠杆菌启动子甲基化水平（APC-MET）作为潜在生物标志物在HCC治疗中的价值：方法：本研究前瞻性地纳入了96例接受局部肿瘤消融治疗的BCLC B期HCC患者。方法：该研究共纳入了96名接受局部肿瘤消融治疗的BCLC B期HCC患者，并对每位患者治疗前和治疗后1个月的血浆中的APC-MET进行了检测。分析了APC-MET对治疗后生存结果和疾病状态的预测价值，并使用cox回归分析法对甲胎蛋白和维生素K缺失-II诱导的蛋白进行了调整：单变量cox回归分析显示，术前APC-MET>0（HR，2.9，95% CI 1.05-8.05，p=0.041）和术后APC-MET>0（HR，3.47，95% CI 1.16-10.4，p=0.026）都是死亡的预测因素，术前APC-MET>0是治疗后疾病进展的预测因素（HR，2.04，95% CI 1.21-3.44，p=0.007）。在多变量模型中，术前APC-MET>0与其他两个传统生物标志物进行调整后，仍能显著预测疾病进展（HR，1.82，95% CI 1.05-3.17，P=0.034）：APC启动子的高甲基化似乎是一种潜在的生物标志物，可以预测局部消融治疗后中晚期HCC患者的生存和疾病进展情况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oncology 医学-肿瘤学

CiteScore

6.00

自引率

2.90%

发文量

审稿时长

6-12 weeks

期刊介绍： Although laboratory and clinical cancer research need to be closely linked, observations at the basic level often remain removed from medical applications. This journal works to accelerate the translation of experimental results into the clinic, and back again into the laboratory for further investigation. The fundamental purpose of this effort is to advance clinically-relevant knowledge of cancer, and improve the outcome of prevention, diagnosis and treatment of malignant disease. The journal publishes significant clinical studies from cancer programs around the world, along with important translational laboratory findings, mini-reviews (invited and submitted) and in-depth discussions of evolving and controversial topics in the oncology arena. A unique feature of the journal is a new section which focuses on rapid peer-review and subsequent publication of short reports of phase 1 and phase 2 clinical cancer trials, with a goal of insuring that high-quality clinical cancer research quickly enters the public domain, regardless of the trial’s ultimate conclusions regarding efficacy or toxicity.