Corpus callosum and cerebellum participate in semantic dysfunction of Parkinson's disease: a diffusion tensor imaging-based cross-sectional study.

IF 1.6 4区 医学 Q4 NEUROSCIENCES Neuroreport Pub Date : 2024-04-03 Epub Date: 2024-03-09 DOI:10.1097/WNR.0000000000002015
Hang Liu, Yuke Zhong, Guohui Liu, Huahua Su, Zhihui Liu, Jiahao Wei, Lijuan Mo, Changhong Tan, Xi Liu, Lifen Chen
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Abstract

Language dysfunction is common in Parkinson's disease (PD) patients, among which, the decline of semantic fluency is usually observed. This study aims to explore the relationship between white matter (WM) alterations and semantic fluency changes in PD patients. 127 PD patients from the Parkinson's Progression Markers Initiative cohort who received diffusion tensor imaging scanning, clinical assessment and semantic fluency test (SFT) were included. Tract-based special statistics, automated fiber quantification, graph-theoretical and network-based analyses were performed to analyze the correlation between WM structural changes, brain network features and semantic fluency in PD patients. Fractional anisotropy of corpus callosum, anterior thalamic radiation, inferior front-occipital fasciculus, and uncinate fasciculus, were positively correlated with SFT scores, while a negative correlation was identified between radial diffusion of the corpus callosum, inferior longitudinal fasciculus, and SFT scores. Automatic fiber quantification identified similar alterations with more details in these WM tracts. Brain network analysis positively correlated SFT scores with nodal efficiency of cerebellar lobule VIII, and nodal local efficiency of cerebellar lobule X. WM integrity and myelin integrity in the corpus callosum and several other language-related WM tracts may influence the semantic function in PD patients. Damage to the cerebellum lobule VIII and lobule X may also be involved in semantic dysfunction in PD patients.

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胼胝体和小脑参与帕金森病的语义功能障碍:基于弥散张量成像的横断面研究。
帕金森病(Parkinson's disease,PD)患者普遍存在语言功能障碍,其中语义流畅性的下降是常见症状。本研究旨在探讨帕金森病患者白质(WM)改变与语义流畅性变化之间的关系。研究纳入了127名帕金森病进展标志物倡议队列中的帕金森病患者,他们接受了弥散张量成像扫描、临床评估和语义流畅性测试(SFT)。通过基于张量的特殊统计、自动纤维量化、图论和网络分析,分析帕金森病患者的WM结构变化、脑网络特征和语义流畅性之间的相关性。胼胝体、丘脑前部辐射、下前枕筋膜和钩状筋膜的分数各向异性与SFT评分呈正相关,而胼胝体、下纵筋膜的径向扩散与SFT评分呈负相关。自动纤维定量分析在这些WM束中发现了更详细的类似改变。脑网络分析发现,SFT评分与小脑第八小叶的结节效率和小脑第十小叶的结节局部效率呈正相关。胼胝体和其他一些与语言相关的WM束中的WM完整性和髓鞘完整性可能会影响帕金森病患者的语义功能。小脑第八小叶和第十小叶的损伤也可能与帕金森病患者的语义功能障碍有关。
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来源期刊
Neuroreport
Neuroreport 医学-神经科学
CiteScore
3.20
自引率
0.00%
发文量
150
审稿时长
1 months
期刊介绍: NeuroReport is a channel for rapid communication of new findings in neuroscience. It is a forum for the publication of short but complete reports of important studies that require very fast publication. Papers are accepted on the basis of the novelty of their finding, on their significance for neuroscience and on a clear need for rapid publication. Preliminary communications are not suitable for the Journal. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool. The core interest of the Journal is on studies that cast light on how the brain (and the whole of the nervous system) works. We aim to give authors a decision on their submission within 2-5 weeks, and all accepted articles appear in the next issue to press.
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