Morphology of the Dorsal Pancreatic Artery and Its Oncological Significance in Pancreatic Cancer.

IF 1.7 4区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY Pancreas Pub Date : 2024-07-01 Epub Date: 2024-03-12 DOI:10.1097/MPA.0000000000002327

Takahiro Kyuno, Isamu Makino, Hirohisa Kitagawa, Hirofumi Terakawa, Ryosuke Gabata, Tomokazu Tokoro, Satoshi Takada, Mitsuyoshi Okazaki, Shinichi Nakanuma, Tetsuo Ohta, Shintaro Yagi

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Abstract

Objectives: Although the dorsal pancreatic artery (DPA) is an important artery that supplies the pancreas, its morphology has not been sufficiently studied. We investigated the morphology of the DPA and the progression of pancreatic cancer along this vessel.

Materials and methods: Overall, 142 patients with pancreatic cancer who underwent surgical resection at Kanazawa University Hospital between 2004 and 2015 were enrolled. We examined the morphology of the DPA using preoperative computed tomography and cancer progression along the DPA using resected specimens. We investigated the anatomical structures surrounding the DPA through cadaveric examination.

Results: The analysis of computed tomography images revealed the presence of the DPA in 141 patients. In typical cases, the DPA divides into a head and a body branch. Histopathological examination revealed cancer progression along the DPA in 32 patients. Cancer progression along the DPA was identified as a factor associated with a poor prognosis in pancreatic head or body cancer. Cadaveric examination showed the presence of abundant nerve and lymphatic tissues along the DPA.

Conclusions: It is important to remove the soft tissue surrounding the DPA during surgery for pancreatic head or body cancer because it may serve as an important route for cancer progression.

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胰腺背动脉的形态及其在胰腺癌中的肿瘤学意义

目的：虽然胰背动脉（DPA）是供应胰腺的重要动脉，但对其形态的研究还不够充分。我们研究了 DPA 的形态以及胰腺癌沿该血管的进展情况：2004年至2015年期间在金泽大学医院接受手术切除的胰腺癌患者共142人。我们使用术前计算机断层扫描检查了 DPA 的形态，并使用切除标本检查了沿 DPA 的癌症进展情况。我们通过尸体解剖研究了DPA周围的解剖结构：结果：对计算机断层扫描图像的分析显示，141 名患者存在 DPA。在典型病例中，DPA分为头支和体支。组织病理学检查显示，32 例患者的癌症沿着 DPA 进展。沿 DPA 的癌症进展被认为是胰头癌或胰体癌预后不良的相关因素。尸体检查显示，DPA沿线存在丰富的神经和淋巴组织：结论：在胰头或胰体癌手术中，切除DPA周围的软组织非常重要，因为它可能是癌症进展的重要途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pancreas 医学-胃肠肝病学

CiteScore

4.70

自引率

3.40%

发文量

289

审稿时长

1 months

期刊介绍： Pancreas provides a central forum for communication of original works involving both basic and clinical research on the exocrine and endocrine pancreas and their interrelationships and consequences in disease states. This multidisciplinary, international journal covers the whole spectrum of basic sciences, etiology, prevention, pathophysiology, diagnosis, and surgical and medical management of pancreatic diseases, including cancer.