The Global Burden of Early-Onset Pancreatic Cancer and Its Risk Factors: A Perspective From Global Burden of Disease Study 2019.

IF 1.7 4区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY Pancreas Pub Date : 2024-05-01 Epub Date: 2024-03-13 DOI:10.1097/MPA.0000000000002331

Pojsakorn Danpanichkul, Kanokphong Suparan, Aunchalee Jaroenlapnopparat, Natchaya Polpichai, Panisara Fangsaard, Areeya Detboon, Pinyada Moolkaew, Adivitch Sripusanapan, Karan Srisurapanont, Yatawee Kanjanakot, Kwanjit Duangsonk, Michael B Wallace, Karn Wijarnpreecha

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Abstract

Objectives: Despite evidence of increased incidence of early-onset pancreatic cancer (EOPC), defined as pancreatic cancer diagnosed in patients below 50 years old, and its risk factors in the Western region, global epidemiological data addressing this issue is still lacking.

Materials and methods: Utilizing data from the Global Burden of Disease Study 2019, we aimed to conduct a comprehensive analysis of the incidence, deaths, and disability-adjusted life years (DALYs) associated with EOPC and its risk factors, including smoking, obesity, and diabetes. The analysis examined the annual percentage change (APC) over the period.

Results: In 2019, the incidence of EOPC surpassed 35,000 cases worldwide. This burden of EOPC tends to be more prevalent in males, as well as in Europe and high SDI countries. However, there is a noticeable upward trend in the burden of EOPC in the Eastern Mediterranean. While there is a global decline in EOPC mortality attributed to smoking (APC -0.33%), there is a concerning increase in mortality associated with diabetes (APC +2.84%) and obesity (APC +2.12%).

Conclusions: The burden of EOPC has been increasing. The mortality is rising mainly from metabolic factors. There is an urgent need for national policy development for reducing the burden of this disease.

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早发胰腺癌的全球负担及其风险因素：2019年全球疾病负担研究透视》。

目的：尽管有证据表明西方地区早发胰腺癌（EOPC）（定义为在50岁以下患者中诊断出的胰腺癌）的发病率及其风险因素有所增加，但全球仍缺乏针对这一问题的流行病学数据：利用《2019 年全球疾病负担研究》（Global Burden of Disease Study 2019）的数据，我们旨在对与胰腺癌及其风险因素（包括吸烟、肥胖和糖尿病）相关的发病率、死亡人数和残疾调整生命年（DALYs）进行全面分析。分析研究了这一时期的年度百分比变化（APC）：结果：2019 年，全球 EOPC 发病率超过 35,000 例。这种 EOPC 负担往往更多发生在男性、欧洲和 SDI 高的国家。然而，在东地中海地区，EOPC 的发病率呈明显上升趋势。虽然全球因吸烟导致的 EOPC 死亡率有所下降（APC -0.33%），但与糖尿病（APC +2.84%）和肥胖（APC +2.12%）相关的死亡率却出现了令人担忧的增长：结论：EOPC 的负担一直在增加。死亡率的上升主要源于代谢因素。迫切需要制定国家政策，以减轻该疾病的负担。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pancreas 医学-胃肠肝病学

CiteScore

4.70

自引率

3.40%

发文量

289

审稿时长

1 months

期刊介绍： Pancreas provides a central forum for communication of original works involving both basic and clinical research on the exocrine and endocrine pancreas and their interrelationships and consequences in disease states. This multidisciplinary, international journal covers the whole spectrum of basic sciences, etiology, prevention, pathophysiology, diagnosis, and surgical and medical management of pancreatic diseases, including cancer.