Toxicological Impact of Bisphenol A on Females' Reproductive System: Review Based on Experimental and Epidemiological Studies.

IF 2.6 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Reproductive Sciences Pub Date : 2024-07-01 Epub Date: 2024-03-26 DOI:10.1007/s43032-024-01521-y
Shahla Chaichian, Fatemeh Khodabandehloo, Ladan Haghighi, Azam Govahi, Mehdi Mehdizadeh, Marziyeh Ajdary, Rajender S Varma
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Abstract

The study encompassing research papers documented in the last two decades pertaining to the possible influence of bisphenol A (BPA) on the fertility of females are appraised with emphasis on the influence of BPA in reproductive organs (uterus and ovaries) and pregnancy outcomes including discussion on the reproductive process (implantation, estrous cycle, hormone secretion); outcomes reveal a connection amongst BPA and female infertility. Ovary, uterus, and its shape as well as function can alter a person's ability to become pregnant by influencing the hypothalamus-pituitary axis in the ovarian model. Additionally, implantation and the estrous cycle may be affected by BPA. However, more research is warranted to comprehend the underlying action mechanisms and to promptly identify any imminent reproductive harm.

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双酚 A 对女性生殖系统的毒理影响:基于实验和流行病学研究的综述。
该研究涵盖了过去二十年中有关双酚 A(BPA)对女性生育能力可能产生的影响的研究论文,重点评估了双酚 A 对生殖器官(子宫和卵巢)和妊娠结果的影响,包括对生殖过程(着床、发情周期、激素分泌)的讨论;结果显示双酚 A 与女性不孕之间存在联系。卵巢、子宫及其形状和功能可通过影响卵巢模型中的下丘脑-垂体轴来改变人的怀孕能力。此外,植入和发情周期也可能受到双酚 A 的影响。然而,要了解其潜在的作用机制并及时发现任何即将发生的生殖危害,还需要进行更多的研究。
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来源期刊
Reproductive Sciences
Reproductive Sciences 医学-妇产科学
CiteScore
5.50
自引率
3.40%
发文量
322
审稿时长
4-8 weeks
期刊介绍: Reproductive Sciences (RS) is a peer-reviewed, monthly journal publishing original research and reviews in obstetrics and gynecology. RS is multi-disciplinary and includes research in basic reproductive biology and medicine, maternal-fetal medicine, obstetrics, gynecology, reproductive endocrinology, urogynecology, fertility/infertility, embryology, gynecologic/reproductive oncology, developmental biology, stem cell research, molecular/cellular biology and other related fields.
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