Mind over Microbes: Investigating the Interplay between Lifestyle Factors, Gut Microbiota, and Brain Health.

IF 3.2 3区医学 Q2 CLINICAL NEUROLOGY Neuroepidemiology Pub Date : 2024-03-26 DOI:10.1159/000538416

Parul Bali, Parth Lal, Madhava Sai Sivapuram, L V Simhachalam Kutikuppala, Pramod Avti, Aarzoo Chanana, Saurabh Kumar, Akshay Anand

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引用次数: 0

Abstract

Background: The gut microbiota (GM) of the human body comprises several species of microorganisms. This microorganism plays a significant role in the physiological and pathophysiological processes of various human diseases.

Methods: The literature review includes studies that describe causative factors that influence GM. The GM is sensitive to various factors like circadian rhythms, environmental agents, physical activity, nutrition, and hygiene that together impact the functioning and composition of the gut microbiome. This affects the health of the host, including the psycho-neural aspects, due to the interconnectivity between the brain and the gut. Hence, this paper examines the relationship of GM with neurodegenerative disorders in the context of these aforesaid factors.

Conclusion: Future studies that identify the regulatory pathways associated with gut microbes can provide a causal link between brain degeneration and the gut at a molecular level. Together, this review could be helpful in designing preventive and treatment strategies aimed at GM, so that neurodegenerative diseases can be treated.

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心理战胜微生物：调查生活方式因素、肠道微生物群与大脑健康之间的相互作用》（Mind Over Microbes: Investigating the Interplay Between Lifestyle Factors, Gut Microbiota, and Brain Health.

背景：人体肠道微生物群（GM）由多种微生物组成。这种微生物在各种人类疾病的生理和病理生理过程中发挥着重要作用：文献综述包括描述影响转基因的致病因素的研究。肠道微生物组对昼夜节律、环境因素、体力活动、营养和卫生等各种因素非常敏感，这些因素共同影响着肠道微生物组的功能和组成。由于大脑和肠道之间的相互联系，这影响着宿主的健康，包括心理神经方面。因此，本文在上述因素的背景下研究了基因改造与神经退行性疾病的关系：结论：未来的研究如果能确定与肠道微生物相关的调节途径，就能在分子水平上提供大脑退化与肠道之间的因果联系。综上所述，本综述有助于设计针对转基因的预防和治疗策略，从而治疗神经退行性疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroepidemiology 医学-公共卫生、环境卫生与职业卫生

CiteScore

9.90

自引率

1.80%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Neuroepidemiology'' is the only internationally recognised peer-reviewed periodical devoted to descriptive, analytical and experimental studies in the epidemiology of neurologic disease. The scope of the journal expands the boundaries of traditional clinical neurology by providing new insights regarding the etiology, determinants, distribution, management and prevention of diseases of the nervous system.