Fabrication of Dual-Functional Micelles Based on Star-Shaped Copolymer for Bioimaging

IF 1 4区化学 Q4 POLYMER SCIENCE Polymer Science, Series A Pub Date : 2024-03-25 DOI:10.1134/s0965545x24600169

Chaofan Liu, Shenglong Liao, Shuyin Zhong, Qingping Song, Jiangang Gao, Ying Lin

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Abstract

Dual-modal fluorescent/magnetic resonance imaging attracts more and more attentions in biomedical applications. Herein, star-shaped poly(ε-caprolactone)-b-poly(N-vinylpyrrolidone) amphiphilic copolymer with a tetrakis-(4-amino)-terminated tetraphenylethylene core was synthesized. Then, dual-functional nano micelles were achieved via a facile self-assembly of the star copolymer and in situ encapsulation of iron oxide nanoparticles. The fluorescent characteristic of the tetraphenylethylene moiety and encapsulation of iron oxide endowed the resultant dual-functional micelles with bright fluorescence and superparamagnetic properties, which indicated that the PCL segments coated on magnetic nanoparticles is effective at separating the conjugated core from iron oxide nanoparticles to minimize fluorescence quenching. The obtained micelles were found to have a good colloidal and fluorescent stability in different environment. In vitro studies revealed that these dual-functional micelles could serve as an effective fluorescent probe to achieve imaging of MCF-7 cells without obvious cytotoxicity. Thus, this work provides a facile strategy to fabricate fluorescent-magnetic dual-functional micelles for dual-modal imaging applications.

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基于星形共聚物的生物成像双功能胶束的制备

摘要双模荧光/磁共振成像在生物医学领域的应用越来越受到关注。本文合成了以四(4-氨基)端四苯乙烯为核心的星形聚(ε-己内酯)-b-聚(N-乙烯基吡咯烷酮)双亲共聚物。然后，通过星型共聚物的简便自组装和氧化铁纳米粒子的原位封装，实现了双功能纳米胶束。四苯基乙烯分子的荧光特性和氧化铁的封装使所制备的双功能胶束具有明亮的荧光和超顺磁性，这表明包覆在磁性纳米粒子上的 PCL 片段能有效地将共轭核与氧化铁纳米粒子分离，从而最大限度地减少荧光淬灭。研究发现，所获得的胶束在不同环境中具有良好的胶体稳定性和荧光稳定性。体外研究表明，这些双功能胶束可作为一种有效的荧光探针对 MCF-7 细胞进行成像，且无明显的细胞毒性。因此，这项工作为制造用于双模式成像的荧光-磁性双功能胶束提供了一种简便的策略。

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来源期刊

Polymer Science, Series A 化学-高分子科学

CiteScore

1.70

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： Polymer Science, Series A is a journal published in collaboration with the Russian Academy of Sciences. Series A includes experimental and theoretical papers and reviews devoted to physicochemical studies of the structure and properties of polymers (6 issues a year). All journal series present original papers and reviews covering all fundamental aspects of macromolecular science. Contributions should be of marked novelty and interest for a broad readership. Articles may be written in English or Russian regardless of country and nationality of authors. All manuscripts are peer reviewed. Online submission via Internet to the Series A, B, and C is available at http://polymsci.ru.