Aspirin administration from early pregnancy versus initiation after 11 weeks of gestation for prevention of pre-eclampsia in high-risk pregnant women: Study protocol for randomized controlled trial.

IF 1.6 Q3 OBSTETRICS & GYNECOLOGY International Journal of Reproductive Biomedicine Pub Date : 2024-02-23 eCollection Date: 2024-01-01 DOI:10.18502/ijrm.v22i1.15244
Sedigheh Hantoushzadeh, Arezoo Behzadian, Mohammad Mehdi Hasheminejad, Faezeh Hasheminejad, Alireza Helal Birjandi, Mojtaba Akbari, Marjan Ghaemi
{"title":"Aspirin administration from early pregnancy versus initiation after 11 weeks of gestation for prevention of pre-eclampsia in high-risk pregnant women: Study protocol for randomized controlled trial.","authors":"Sedigheh Hantoushzadeh, Arezoo Behzadian, Mohammad Mehdi Hasheminejad, Faezeh Hasheminejad, Alireza Helal Birjandi, Mojtaba Akbari, Marjan Ghaemi","doi":"10.18502/ijrm.v22i1.15244","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Pre-eclampsia (PE) is a multiorgan disorder that affects 2-5% of all pregnant women. Present recommendations for when to start aspirin in high-risk women are after 11 wk of gestation.</p><p><strong>Objective: </strong>We present a protocol to investigate the effectiveness of aspirin use from early pregnancy, which is a randomized controlled trial to assess whether prescribed low-dose aspirin from early pregnancy reduces the prevalence of early and late-onset PE. Additionally, to compare the effectiveness of aspirin administration before and after 11 wk in reducing the occurrence of PE?</p><p><strong>Materials and methods: </strong>All pregnancies at risk of PE, according to demographic and midwifery history, who are referred to the Maternal-Fetal Clinic of Tehran University hospital, Tehran, Iran were invited to take part in the trial. The outcomes of pregnancy and newborns will be gathered and analyzed. The first registration for the pilot study was in January 2023, and the participants were recognized as high-risk for PE. In addition, enrollment in the main study will begin as of October 2023.</p>","PeriodicalId":14386,"journal":{"name":"International Journal of Reproductive Biomedicine","volume":"22 1","pages":"69-80"},"PeriodicalIF":1.6000,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10963873/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Reproductive Biomedicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18502/ijrm.v22i1.15244","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Pre-eclampsia (PE) is a multiorgan disorder that affects 2-5% of all pregnant women. Present recommendations for when to start aspirin in high-risk women are after 11 wk of gestation.

Objective: We present a protocol to investigate the effectiveness of aspirin use from early pregnancy, which is a randomized controlled trial to assess whether prescribed low-dose aspirin from early pregnancy reduces the prevalence of early and late-onset PE. Additionally, to compare the effectiveness of aspirin administration before and after 11 wk in reducing the occurrence of PE?

Materials and methods: All pregnancies at risk of PE, according to demographic and midwifery history, who are referred to the Maternal-Fetal Clinic of Tehran University hospital, Tehran, Iran were invited to take part in the trial. The outcomes of pregnancy and newborns will be gathered and analyzed. The first registration for the pilot study was in January 2023, and the participants were recognized as high-risk for PE. In addition, enrollment in the main study will begin as of October 2023.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
在预防高危孕妇先兆子痫方面,从妊娠早期开始服用阿司匹林与在妊娠 11 周后开始服用阿司匹林:随机对照试验研究方案。
背景:子痫前期(PE)是一种多器官疾病,影响2-5%的孕妇。目前关于高危妇女何时开始服用阿司匹林的建议是在妊娠 11 周后:我们提出了一项从妊娠早期开始服用阿司匹林的有效性研究方案,这是一项随机对照试验,旨在评估从妊娠早期开始服用小剂量阿司匹林是否能降低早发和晚发 PE 的发病率。此外,还将比较 11 周前和 11 周后服用阿司匹林对减少 PE 发生的有效性:所有根据人口统计学和助产史转诊到伊朗德黑兰大学医院母胎诊所的有 PE 风险的孕妇均被邀请参加试验。将收集并分析妊娠和新生儿的结果。试点研究的首次登记时间为 2023 年 1 月,参与者被认定为 PE 高危人群。此外,主要研究将于 2023 年 10 月开始注册。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
2.40
自引率
7.70%
发文量
93
审稿时长
16 weeks
期刊介绍: The International Journal of Reproductive BioMedicine (IJRM), formerly published as "Iranian Journal of Reproductive Medicine (ISSN: 1680-6433)", is an international monthly scientific journal for who treat and investigate problems of infertility and human reproductive disorders. This journal accepts Original Papers, Review Articles, Short Communications, Case Reports, Photo Clinics, and Letters to the Editor in the fields of fertility and infertility, ethical and social issues of assisted reproductive technologies, cellular and molecular biology of reproduction including the development of gametes and early embryos, assisted reproductive technologies in model system and in a clinical environment, reproductive endocrinology, andrology, epidemiology, pathology, genetics, oncology, surgery, psychology, and physiology. Emerging topics including cloning and stem cells are encouraged.
期刊最新文献
Carotid artery intima-media thickness in women with polycystic ovary syndrome: A cross-sectional study. Corrigendum to "The report of ovarian tissue transplant in Iran: A case report" [Int J Reprod BioMed 2024; 22: 323-328]. Diagnosis of hydatidiform moles using p57 immunohistochemistry and chromogenic insitu hybridization: A retrospective study. Effect of dietary approaches to stop hypertension and curcumin co-administration on glycemic parameters in polycystic ovary syndrome: An RCT. Effect of online problem-solving counseling on the sexual anxiety and intimacy of women with recurrent pregnancy loss: A clinical trial.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1