The Genetic Association of MMP-2 Gene Polymorphisms with the Susceptibility to Alzheimer's Disease.

IF 2.5 4区医学 Q3 NEUROSCIENCES Journal of integrative neuroscience Pub Date : 2024-03-04 DOI:10.31083/j.jin2303052

Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao

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Abstract

Background: A hospital-based case-control study was carried out to elucidate the association of Matrix metalloproteinase-2 (MMP-2) gene candidate polymorphisms with the susceptibility to Alzheimer's disease (AD) in the Chinese Han population.

Methods: A total of 200 AD cases and an equal number of healthy controls were recruited to undergo genotyping of specific loci within the MMP-2 gene loci (rs243866, rs2285053, rs243865). Logistic regression analysis was applied to examine the association of the genotypes and alleles of MMP-2 gene polymorphisms with AD after adjusting clinical confounding factors.

Results: Within AD group, a high proportion of rs243866 genotype carriers were found, and the difference remained significant despite adjusting for other clinical indicators. Among individuals with the rs243866 AA genotype and rs243865 TT genotype, the onset age of AD occurred at a younger age. Early-onset AD risk in rs243866 AA genotype carriers was 6.528 times higher than those in GG genotype carriers, and individuals with rs243865 TT genotype faced a 4.048-fold increased risk compared to those with CC genotype.

Conclusions: MMP-2 gene rs243866 and rs243865 polymorphisms were closely associated with the onset age of AD. The presence of rs243866 AA genotype emerged as a crucial predictor of AD risk.

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MMP-2基因多态性与阿尔茨海默病易感性的遗传关联。

研究背景以医院为基础的病例对照研究旨在阐明中国汉族人群中基质金属蛋白酶-2（MMP-2）基因候选多态性与阿尔茨海默病（AD）易感性的关系：方法：招募200例AD病例和相同数量的健康对照，对MMP-2基因位点（rs243866、rs2285053和rs243865）中的特定位点进行基因分型。在调整临床混杂因素后，采用逻辑回归分析法研究MMP-2基因多态性的基因型和等位基因与AD的关系：结果：在AD组中，rs243866基因型携带者比例较高，尽管调整了其他临床指标，但差异仍然显著。在 rs243866 AA 基因型和 rs243865 TT 基因型携带者中，AD 的发病年龄较小。rs243866 AA基因型携带者早发AD的风险是GG基因型携带者的6.528倍，rs243865 TT基因型携带者的风险是CC基因型携带者的4.048倍：MMP-2基因rs243866和rs243865多态性与AD的发病年龄密切相关。rs243866的AA基因型是预测AD风险的关键因素。

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来源期刊

Journal of integrative neuroscience 医学-神经科学

CiteScore

2.80

自引率

5.60%

发文量

173

审稿时长

2 months

期刊介绍： JIN is an international peer-reviewed, open access journal. JIN publishes leading-edge research at the interface of theoretical and experimental neuroscience, focusing across hierarchical levels of brain organization to better understand how diverse functions are integrated. We encourage submissions from scientists of all specialties that relate to brain functioning.